Breast cancer exosomes contribute to pre-metastatic niche formation and promote bone metastasis of tumor cells

• Published in: Theranostics Vol. 11; no. 3; pp. 1429 - 1445
• Main Authors: Yuan, Xinxin, Qian, Niansong, Ling, Shukuan, Li, Yuheng, Sun, Weijia, Li, Jianwei, Du, Ruikai, Zhong, Guohui, Liu, Caizhi, Yu, Guotao, Cao, Dengchao, Liu, Zizhong, Wang, Yinbo, Qi, Zhihong, Yao, Yingpeng, Wang, Fang, Liu, Jingjing, Hao, Shanshan, Jin, Xiaoyan, Zhao, Yinlong, Xue, Jianqi, Zhao, Dingsheng, Gao, Xingcheng, Liang, Shuai, Li, Youyou, Song, Jinping, Yu, Shuyang, Li, Yingxian
• Format: Journal Article
• Language: English
• Published: Australia Ivyspring International Publisher Pty Ltd 2021; Ivyspring International Publisher
• Subjects: Astronauts; Bone density; Breast cancer; Cancer therapies; Chemotherapy; Collagen; Experiments; Kinases; Medical diagnosis; Metastasis; Mortality; Research Paper; United States > US; China; pre-metastatic niche; miR-21; bone metastasis; exosomes; osteoclasts

Breast cancer preferentially develops osteolytic bone metastasis, which makes patients suffer from pain, fractures and spinal cord compression. Accumulating evidences have shown that exosomes play an irreplaceable role in pre-metastatic niche formation as a communication messenger. However, the func...