Effect of 24 Weeks of Statin Therapy on Systemic and Vascular Inflammation in HIV-Infected Subjects Receiving Antiretroviral Therapy

• Published in: The Journal of infectious diseases Vol. 209; no. 8; pp. 1156 - 1164
• Main Authors: Eckard, Allison Ross, Jiang, Ying, Debanne, Sara M., Funderburg, Nicholas T., McComsey, Grace A.
• Format: Journal Article
• Language: English
• Published: Oxford Oxford University Press 15.04.2014
• Subjects: 1-Alkyl-2-acetylglycerophosphocholine Esterase - blood; Adult; Anti-Retroviral Agents - therapeutic use; Biological and medical sciences; Biomarkers; Cardiovascular diseases; Cardiovascular Diseases - blood; Cardiovascular Diseases - drug therapy; Cholesterol, LDL - blood; Cholesterols; Coagulation; Double-Blind Method; Female; Fluorobenzenes - therapeutic use; Fundamental and applied biological sciences. Psychology; HIV; HIV infections; HIV Infections - blood; HIV Infections - drug therapy; HIV/AIDS; Human immunodeficiency virus; Human viral diseases; Humans; Hydroxymethylglutaryl-CoA Reductase Inhibitors - therapeutic use; Infectious diseases; Inflammation; Major and Brief Reports; Male; Medical sciences; Microbiology; Middle Aged; Nadir; Placebos; Prospective Studies; Pyrimidines - therapeutic use; Regression Analysis; Risk Factors; RNA; Rosuvastatin Calcium; Sulfonamides - therapeutic use; T lymphocytes; Treatment Outcome; Vasculitis - blood; Vasculitis - drug therapy; Viral diseases; Viral diseases of the lymphoid tissue and the blood. Aids; Infection; Immunopathology; Antiretroviral agent; Treatment; Viral disease; Antiviral; AIDS; Statin derivative; Inflammation; Immune deficiency; Antilipemic agent; cardiovascular disease; HIV; statin; inflammation; coagulation; lipoprotein-associated phospholipase A2

Background. Human immunodeficiency virus (HIV)-infected individuals are at increased risk of cardiovascular disease (CVD) due in part to inflammation. Statins decrease inflammation in the general population, but their effect during HIV infection is largely unknown. Methods. This is an ongoing random...