A new oral formulation for the release of sodium butyrate in the ileo-cecal region and colon

• Published in: World journal of gastroenterology : WJG Vol. 13; no. 7; pp. 1079 - 1084
• Main Author: Roda, Aldo
• Format: Journal Article
• Language: English
• Published: United States Department of Pharmaceutical Sciences,University of Bologna,Via Belmeloro 6,Bologna 40126,Italy%Department of Internal Medicine and Gastroenterology,University of Bologna,via Massarenti 9,Bologna 40126,Italy 21.02.2007; Baishideng Publishing Group Co., Limited
• Subjects: Administration, Oral; Adolescent; Adult; Aged; Butyrates - administration & dosage; Butyrates - metabolism; Butyrates - therapeutic use; Carbon Dioxide - metabolism; Carbon Isotopes; Cecum - metabolism; Chemistry, Pharmaceutical; Colon - metabolism; Crohn Disease - drug therapy; Female; Humans; Ileum - metabolism; Male; Middle Aged; Rapid Communication; Sodium - administration & dosage; Sodium - metabolism; Sodium - therapeutic use; Tablets, Enteric-Coated; Taurochenodeoxycholic Acid - blood; 丁酸钠; 公式化; 列方程式; Sodium butyrate; Inflammatory bowel diseases; Controlled release formulation; Stable isotope; Breath test; Crohn's disease; Pharmacokinetics; Ulcerative colitis

AIM： To develop a new formulation with hydroxy propyl methyl cellulose and Shellac coating for extended and selective delivery of butyrate in the ileo-caecal region and colon. METHODS： One-gram sodium butyrate coated tablets containing ^13C-butyrate were orally administered to 12 healbhy subjects an...