Comparing Various Off-the-Shelf Methods for Bone Tissue Engineering in a Large-Animal Ectopic Implantation Model: Bone Marrow, Allogeneic Bone Marrow Stromal Cells, and Platelet Gel

• Published in: Tissue engineering. Part A Vol. 14; no. 8; pp. 1435 - 1443
• Main Authors: Geuze, Ruth E., Kruyt, Moyo C., Verbout, Abraham J., Alblas, Jacqueline, Dhert, Wouter J.A.
• Format: Journal Article
• Language: English
• Published: United States Mary Ann Liebert, Inc 01.08.2008
• Subjects: Animals; Blood Platelets - metabolism; Bone and Bones - physiology; Bone marrow; Bone Marrow - metabolism; Bone Marrow Cells - cytology; Bone Marrow Cells - metabolism; Bones; Comparative studies; Female; Gels; Goats; Methods; Osteogenesis; Physiological aspects; Prosthesis Implantation; Skin & tissue grafts; Stromal Cells - cytology; Tissue engineering; Tissue Engineering - methods; Tissue Scaffolds; Transplantation; Netherlands

Construction of bone grafts for regenerative medicine would highly benefit from off-the-shelf components, such as allogeneic bone marrow stromal cells (BMSCs) and blood-derived growth factors from platelet concentrate. Although allogeneic BMSCs are considered immunosuppressive, their use in transpla...