Fully Automated GMP-Compliant Synthesis of [ 18 F]FE-PE2I

• Published in: Pharmaceuticals (Basel, Switzerland) Vol. 14; no. 7; p. 601
• Main Authors: Bratteby, Klas, Denholt, Charlotte Lund, Lehel, Szabolcs, Petersen, Ida Nymann, Madsen, Jacob, Erlandsson, Maria, Ohlsson, Tomas, Herth, Matthias Manfred, Gillings, Nic
• Format: Journal Article
• Language: English
• Published: Switzerland MDPI AG 22.06.2021; MDPI
• Subjects: [18F]FE-PE2I; Automation; Ethanol; Experiments; Fluorides; fluorine-18; GMP; Good Manufacturing Practice; Radiation; radiochemistry; fluorine-18; [18F]FE-PE2I; automation; GMP; radiochemistry

In the struggle to understand and accurately diagnose Parkinson's disease, radiopharmaceuticals and medical imaging techniques have played a major role. By being able to image and quantify the dopamine transporter density, noninvasive diagnostic imaging has become the gold standard. In the shif...