Venous Hypertension, Inflammation and Valve Remodeling

• Published in: European journal of vascular and endovascular surgery Vol. 28; no. 5; pp. 484 - 493
• Main Authors: Takase, S., Pascarella, L., Lerond, L., Bergan, J.J., Schmid-Schönbein, G.W.
• Format: Journal Article
• Language: English
• Published: England Elsevier Ltd 01.11.2004
• Subjects: Animals; Anti-Inflammatory Agents - therapeutic use; Apoptosis; Arterio-venous fistula; Flavonoids - therapeutic use; Granulocytes; Leucocyte membrane adhesion; Lymphocyte; Macrophages; Male; Matrix metalloproteinase; Membrane adhesion molecules; Models, Animal; Monocytes; Rats; Rats, Wistar; Saphenous Vein - drug effects; Saphenous Vein - immunology; Saphenous Vein - physiopathology; Transcription factor NFκB; Valve reflux; Venous Insufficiency - immunology; Venous Pressure - drug effects; Venous Pressure - immunology; Venous Pressure - physiology; Leucocyte membrane adhesion; Monocytes; Granulocytes; Matrix metalloproteinase; Transcription factor NFκB; Macrophages; Lymphocyte; Arterio-venous fistula; Valve reflux; Membrane adhesion molecules; Apoptosis

Objectives. To identify possible mechanisms for destruction of valves in chronic venous hypertension and the results of treatment with an anti-inflammatory micronized purified flavonoid fraction. Material and methods. The saphenous vein valves in a rat model of venous hypertension caused by a femora...