Withdrawal-Associated Increases and Decreases in Functional Neural Connectivity Associated with Altered Emotional Regulation in Alcoholism

• Published in: Neuropsychopharmacology (New York, N.Y.) Vol. 37; no. 10; pp. 2267 - 2276
• Main Authors: O'Daly, Owen G, Trick, Leanne, Scaife, Jess, Marshall, Jane, Ball, David, Phillips, Mary L, Williams, Stephen SC, Stephens, David N, Duka, Theodora
• Format: Journal Article
• Language: English
• Published: Basingstoke Nature Publishing Group 01.09.2012
• Subjects: Abstinence; Addictive behaviors; Adult; Adult and adolescent clinical studies; Alcoholics; Alcoholism; Alcoholism - complications; Alcoholism - psychology; Alcoholism and acute alcohol poisoning; Amygdala; Amygdala - physiopathology; bed nucleus; Biological and medical sciences; Brain - physiopathology; Case-Control Studies; Central Nervous System Depressants - adverse effects; Cerebral Cortex - physiopathology; Colliculus; Cortex (frontal); Cortex (prefrontal); Detoxification; Drug abuse; Emotional regulation; Emotions; Ethanol; Ethanol - adverse effects; Facial Expression; Fear; Female; Functional magnetic resonance imaging; Functional Neuroimaging; Globus pallidus; Globus Pallidus - physiopathology; Humans; Information processing; Inventories; Magnetic Resonance Imaging; Male; Medical records; Medical sciences; Middle Aged; Neural networks; Neural Pathways - physiopathology; Neurosciences; Original; Patients; Pattern Recognition, Visual; Perception; Perceptual Disorders - etiology; Perceptual Disorders - physiopathology; Physiology; Psychology. Psychoanalysis. Psychiatry; Psychopathology. Psychiatry; Septal Nuclei - physiopathology; Severity of Illness Index; Stress; Stria terminalis; Substance Withdrawal Syndrome - complications; Substance Withdrawal Syndrome - psychology; Toxicology; United Kingdom > UK; Emotional expression; Amygdala; Alcoholism; Central nervous system; Exploration; Basal ganglion; Emotion emotionality; Prefrontal cortex; insula; Nuclear magnetic resonance imaging; detoxifcation; Encephalon; Fear; fMRI; fearful facial expression; Disintoxication; Functional magnetic resonance imaging; Self regulation; Face; Insular cortex; Amygdaloid nucleus; Facial expression; Functional imaging

Alcoholic patients who have undergone multiple detoxifications/relapses show altered processing of emotional signals. We performed functional magnetic resonance imaging during performance of implicit and explicit versions of a task in which subjects were presented with morphs of fearful facial emoti...