Myticalins: A Novel Multigenic Family of Linear, Cationic Antimicrobial Peptides from Marine Mussels (Mytilus spp.)

• Published in: Marine drugs Vol. 15; no. 8; p. 261
• Main Authors: Leoni, Gabriele, De Poli, Andrea, Mardirossian, Mario, Gambato, Stefano, Florian, Fiorella, Venier, Paola, Wilson, Daniel, Tossi, Alessandro, Pallavicini, Alberto, Gerdol, Marco
• Format: Journal Article
• Language: English
• Published: Switzerland MDPI AG 22.08.2017; MDPI
• Subjects: Adaptation; Animals; Anti-Bacterial Agents - chemistry; Anti-Bacterial Agents - pharmacology; Antiinfectives and antibacterials; Antimicrobial agents; Antimicrobial Cationic Peptides - chemistry; Antimicrobial Cationic Peptides - pharmacology; antimicrobial peptide; Antimicrobial peptides; Aquatic Organisms; Bacteria; Biocompatibility; Bioinformatics; Bivalvia; Cationic antimicrobial peptides; Cations; Conserved sequence; Data processing; Freshwater molluscs; Genomes; Gills; Gram-negative bacteria; Gram-Negative Bacteria - drug effects; Gram-Positive Bacteria - drug effects; hypervariability; innate immunity; Invertebrates; Marine invertebrates; Marine molluscs; Marine technology; Microbial Sensitivity Tests; Mollusks; Mussels; Mytilus galloprovincialis; Next-generation sequencing; Peptides; Phytotherapy; proline-rich; Sequencing; Tissue; Variability; proline-rich; innate immunity; Mytilus galloprovincialis; antimicrobial peptide; hypervariability

The application of high-throughput sequencing technologies to non-model organisms has brought new opportunities for the identification of bioactive peptides from genomes and transcriptomes. From this point of view, marine invertebrates represent a potentially rich, yet largely unexplored resource fo...