Mitochondria-targeted plastoquinone derivatives as tools to interrupt execution of the aging program. 3. Inhibitory effect of SkQ1 on tumor development from p53-deficient cells

• Published in: Biochemistry (Moscow) Vol. 73; no. 12; pp. 1300 - 1316
• Main Authors: Agapova, L. S, Chernyak, B. V, Domnina, L. V, Dugina, V. B, Efimenko, A. Yu, Fetisova, E. K, Ivanova, O. Yu, Kalinina, N. I, Khromova, N. V, Kopnin, B. P, Kopnin, P. B, Korotetskaya, M. V, Lichinitser, M. R, Lukashev, A. L, Pletjushkina, O. Yu, Popova, E. N, Skulachev, M. V, Shagieva, G. S, Stepanova, E. V, Titova, E. V, Tkachuk, V. A, Vasiliev, J. M, Skulachev, V. P
• Format: Journal Article
• Language: English
• Published: Dordrecht Dordrecht : SP MAIK Nauka/Interperiodica 01.12.2008; SP MAIK Nauka/Interperiodica; Springer Nature B.V
• Subjects: Aging; Animal models; Animals; Antioxidants; ATP-Binding Cassette, Sub-Family B, Member 1 - genetics; ATP-Binding Cassette, Sub-Family B, Member 1 - metabolism; Biochemistry; Biomedical and Life Sciences; Biomedicine; Bioorganic Chemistry; Cell Differentiation - drug effects; Cell Line, Tumor; Cell Proliferation - drug effects; Cell Transformation, Neoplastic - drug effects; Cells, Cultured; Female; Humans; Life Sciences; Male; Mice; Mice, Inbred C57BL; Mice, Knockout; Mice, Nude; Microbiology; Mitochondria; Mitochondria - chemistry; Mitochondria - drug effects; Mitochondria - metabolism; Neoplasm Transplantation; Neoplasms - drug therapy; Neoplasms - metabolism; Neoplasms - physiopathology; Neovascularization, Pathologic - drug therapy; Oncology; Plastoquinone - analogs & derivatives; Plastoquinone - metabolism; Plastoquinone - pharmacology; Reactive Oxygen Species - metabolism; Transplantation, Heterologous; Tumor Suppressor Protein p53 - antagonists & inhibitors; Tumor Suppressor Protein p53 - genetics; Tumor Suppressor Protein p53 - metabolism; Tumors; mitochondria-targeted antioxidant; tumorigenesis; tumor cells

It was proposed that increased level of mitochondrial reactive oxygen species (ROS), mediating execution of the aging program of an organism, could also be critical for neoplastic transformation and tumorigenesis. This proposal was addressed using new mitochondria-targeted antioxidant SkQ1 (10-(6�...