Frondanol, a Nutraceutical Extract from Cucumaria frondosa, Attenuates Colonic Inflammation in a DSS-Induced Colitis Model in Mice

• Published in: Marine drugs Vol. 16; no. 5; p. 148
• Main Authors: Subramanya, Sandeep B., Chandran, Sanjana, Almarzooqi, Saeeda, Raj, Vishnu, Al Zahmi, Aisha Salem, Al Katheeri, Radeya Ahmed, Al Zadjali, Samira Ali, Collin, Peter D., Adrian, Thomas E.
• Format: Journal Article
• Language: English
• Published: Switzerland MDPI AG 30.04.2018; MDPI
• Subjects: Animals; Anti-inflammatory agents; Antigens, Differentiation - genetics; Antigens, Differentiation - metabolism; Body weight; Chemokine CXCL2 - genetics; Chemokine CXCL2 - metabolism; Colitis; Colitis - chemically induced; Colitis - drug therapy; Colon; colon inflammation; Complex Mixtures - chemistry; Complex Mixtures - pharmacology; Cucumaria - chemistry; Cucumaria frondosa; Cytokines; Cytokines - genetics; Cytokines - metabolism; Dextran; Dextran Sulfate; Dietary Supplements; Disease control; DNA; Drinking water; DSS colitis; ELISA; Enzyme-linked immunosorbent assay; Frondanol; Functional foods & nutraceuticals; Gene expression; Gene Expression Regulation - drug effects; Histology; Inflammation; Inflammatory bowel disease; Interleukin 6; Intestine; Intestines; Leukotriene B4; Lipids; Macrophage inflammatory protein; Macrophages; Male; Marine invertebrates; Mice; Mice, Inbred C57BL; Neutrophils; Nucleotide sequence; PCR; Peroxidase; Peroxidase - metabolism; Polymerase chain reaction; Proteins; RNA, Messenger - genetics; RNA, Messenger - metabolism; Rodents; Sodium; Sodium sulfate; Tissue; Tumor necrosis factor-α; DSS colitis; colon inflammation; Cucumaria frondosa; Frondanol

Frondanol is a nutraceutical lipid extract of the intestine of the edible Atlantic sea cucumber, Cucumaria frondosa, with potent anti-inflammatory effects. In the current study, we investigated Frondanol as a putative anti-inflammatory compound in an experimental model of colonic inflammation. C57BL...