Haploinsufficiency of mechanistic target of rapamycin ameliorates bag3 cardiomyopathy in adult zebrafish

• Published in: Disease models & mechanisms Vol. 12; no. 10
• Main Authors: Ding, Yonghe, Dvornikov, Alexey V., Ma, Xiao, Zhang, Hong, Wang, Yong, Lowerison, Matthew, Packard, Rene R., Wang, Lei, Chen, Jun, Zhang, Yuji, Hsiai, Tzung, Lin, Xueying, Xu, Xiaolei
• Format: Journal Article
• Language: English
• Published: England The Company of Biologists Ltd 01.10.2019; The Company of Biologists
• Subjects: Adaptor Proteins, Signal Transducing - genetics; Adaptor Proteins, Signal Transducing - metabolism; Amino Acid Sequence; Anemia; Animals; Apoptosis Regulatory Proteins - genetics; Apoptosis Regulatory Proteins - metabolism; Base Sequence; bcl2-associated athanogene 3; Cardiac function; Cardiomyopathies - genetics; Cardiomyopathies - pathology; Cardiomyopathy; danio rerio; dilated cardiomyopathy; Enzymes; Gene Expression Profiling; Genes; Genetic engineering; Genome editing; Genomes; Haploinsufficiency - genetics; Heart; Kinases; mtor; Mutation; Mutation - genetics; Myocardium - metabolism; Myocardium - pathology; Phenotype; Proteins; Signal Transduction; TOR Serine-Threonine Kinases - metabolism; Transcription Activator-Like Effector Nucleases; Zebra; Zebrafish; Zebrafish - genetics; Zebrafish Proteins - genetics; Zebrafish Proteins - metabolism; mTOR; BCL2-associated athanogene 3; Dilated cardiomyopathy; Danio rerio

The adult zebrafish is an emerging vertebrate model for studying human cardiomyopathies; however, whether the simple zebrafish heart can model different subtypes of cardiomyopathies, such as dilated cardiomyopathy (DCM), remains elusive. Here, we generated and characterized an inherited DCM model in...