Polycationic PAMAM ameliorates obesity-associated chronic inflammation and focal adiposity

• Published in: Biomaterials Vol. 293; p. 121850
• Main Authors: Huang, Baoding, Wan, Qianfen, Li, Tianyu, Yu, Lexiang, Du, Wen, Calhoun, Carmen, Leong, Kam W., Qiang, Li
• Format: Journal Article
• Language: English
• Published: Netherlands Elsevier Ltd 01.02.2023
• Subjects: Adiposity; Animals; biocompatible materials; Body Weight; Chronic inflammation; Diet, High-Fat; human serum albumin; Humans; inflammation; Inflammation - drug therapy; Inflammation - metabolism; Local fat reduction; Metabolic diseases; Mice; Mice, Inbred C57BL; Obesity; Obesity - complications; Obesity - drug therapy; Obesity - genetics; Polycationic PAMAM; public health; RNA; subcutaneous fat; Polycationic PAMAM; Obesity; Metabolic diseases; Chronic inflammation; Local fat reduction

As a surging public health crisis, obesity and overweight predispose individuals to various severe comorbidities contributed by the accompanying chronic inflammation. However, few options exist for tackling chronic inflammation in obesity or inhibiting depot-specific adiposity. Here, we report that...