Chronic fornix deep brain stimulation in a transgenic Alzheimer’s rat model reduces amyloid burden, inflammation, and neuronal loss

• Published in: Brain Structure and Function Vol. 224; no. 1; pp. 363 - 372
• Main Authors: Leplus, Aurelie, Lauritzen, Inger, Melon, Christophe, Kerkerian-Le Goff, Lydia, Fontaine, Denys, Checler, Frederic
• Format: Journal Article
• Language: English
• Published: Berlin/Heidelberg Springer Berlin Heidelberg 01.01.2019; Springer Nature B.V; Springer Verlag
• Subjects: Alzheimer's disease; Amyloidosis; Biomedical and Life Sciences; Biomedicine; Cell Biology; Cognitive ability; Deep brain stimulation; Fornix; Gliosis; Hippocampus; Inflammation; Life Sciences; Neurology; Neurons and Cognition; Neuroprotection; Neurosciences; Original Article; Rodents; Fornix; Neuroprotection; Neuronal loss; Alzheimer rat model; Alzheimer disease; Deep brain stimulation; Chronic stimulation; Neuromodulation; Beta-amyloid plaques

Recent studies have suggested deep brain stimulation (DBS) as a promising therapy in patients with Alzheimer’s disease (AD). Particularly, the stimulation of the forniceal area was found to slow down the cognitive decline of some AD patients, but the biochemical and anatomical modifications underlyi...