Postlumpectomy Focal Brachytherapy for Simultaneous Treatment of Surgical Cavity and Draining Lymph Nodes

• Published in: International journal of radiation oncology, biology, physics Vol. 79; no. 3; pp. 948 - 955
• Main Authors: Hrycushko, Brian A., Li, Shihong, Shi, Chengyu, Goins, Beth, Liu, Yaxi, Phillips, William T., Otto, Pamela M., Bao, Ande
• Format: Journal Article
• Language: English
• Published: New York, NY Elsevier Inc 01.03.2011; Elsevier
• Subjects: Animals; Axilla; BETA DECAY RADIOISOTOPES; BETA-MINUS DECAY RADIOISOTOPES; Biological and medical sciences; BODY; BRACHYTHERAPY; Brachytherapy - methods; Breast cancer; Breast Neoplasms - radiotherapy; CAVITIES; COUNTING TECHNIQUES; DAYS LIVING RADIOISOTOPES; DIAGNOSTIC TECHNIQUES; DISEASES; DOSES; ELECTRON CAPTURE RADIOISOTOPES; Feasibility Studies; Female; Focal brachytherapy; GLANDS; Gynecology. Andrology. Obstetrics; HEAVY NUCLEI; Hematology, Oncology and Palliative Medicine; HOURS LIVING RADIOISOTOPES; Humans; INTERNAL CONVERSION RADIOISOTOPES; ISOMERIC TRANSITION ISOTOPES; ISOTOPES; KERNELS; LIPIDS; Liposome; LIPOSOMES; Lymph node; LYMPH NODES; Lymph Nodes - radiation effects; Lymphatic Irradiation - methods; LYMPHATIC SYSTEM; Mammary gland diseases; MAMMARY GLANDS; Mastectomy, Segmental; Medical sciences; MEDICINE; MINUTES LIVING RADIOISOTOPES; Nanoparticles; NANOSTRUCTURES; Neoplasm, Residual; NEOPLASMS; NUCLEAR MEDICINE; NUCLEI; ODD-ODD NUCLEI; ORGANIC COMPOUNDS; ORGANS; PARTICLES; POINT KERNELS; RADIATION DOSES; RADIOISOTOPE SCANNING; RADIOISOTOPES; Radioisotopes - administration & dosage; RADIOLOGY; RADIOLOGY AND NUCLEAR MEDICINE; Radionuclide; RADIOTHERAPY; Radiotherapy Dosage; Rhenium - administration & dosage; RHENIUM 186; RHENIUM 188; RHENIUM ISOTOPES; SCINTISCANNING; SURGERY; THERAPY; Tumors; YEARS LIVING RADIOISOTOPES; Liposome; Radionuclide; Breast cancer; Lymph node; Focal brachytherapy; Breast disease; Malignant tumor; Radiotherapy; Mammary gland diseases; Treatment; Surgery; Curietherapy; Cancer
• ISSN: 0360-3016; 1879-355X; 1879-355X
• DOI: 10.1016/j.ijrobp.2010.05.062

The primary objective was to investigate a novel focal brachytherapy technique using lipid nanoparticle (liposome)–carried β-emitting radionuclides (rhenium-186 [ 186Re]/rhenium-188 [ 188Re]) to simultaneously treat the postlumpectomy surgical cavity and draining lymph nodes. Cumulative activity dis...