Genetic Variation in Immune Regulation and DNA Repair Pathways and Stomach Cancer in China

• Published in: Cancer epidemiology, biomarkers & prevention Vol. 18; no. 8; pp. 2304 - 2309
• Main Authors: Hussain, Shehnaz K., Mu, Li-Na, Cai, Lin, Chang, Shen-Chih, Park, Sungshim Lani, Oh, Sam S., Wang, Yiren, Goldstein, Binh Y., Ding, Bao-Guo, Jiang, Qingwu, Rao, Jianyu, You, Nai-Chieh Y., Yu, Shun-Zhang, Papp, Jeanette C., Zhao, Jin-Kou, Wang, Hua, Zhang, Zuo-Feng
• Format: Journal Article
• Language: English
• Published: Philadelphia, PA American Association for Cancer Research 01.08.2009
• Subjects: Biological and medical sciences; Case-Control Studies; China; Cyclooxygenase 2 - genetics; DNA repair; DNA Repair - genetics; DNA-Binding Proteins - genetics; Endonucleases - genetics; Female; Gastroenterology. Liver. Pancreas. Abdomen; genetic polymorphism; Genetic Predisposition to Disease; Genotype; Haplotypes; Humans; Immune System Phenomena - genetics; inflammation; Male; Medical sciences; Middle Aged; Nuclear Proteins - genetics; Odds Ratio; Polymorphism, Single Nucleotide; SNP; stomach cancer; Stomach Neoplasms - genetics; Stomach Neoplasms - immunology; Stomach. Duodenum. Small intestine. Colon. Rectum. Anus; Transcription Factors - genetics; Tumors; Asia; China; Genetic variability; Genotype; Immune regulation; Malignant tumor; Stomach cancer; DNA repair; Cancerology; DNA; Digestive diseases; Genetics; Cancer; Gastric disease; Polymorphism

The incidence of stomach cancer is high in certain parts of the world, particularly in China. Chronic Helicobacter pylori infection is the main risk factor, yet the vast majority of infected individuals remain unaffected with cancer, suggesting an important role of other risk factors. We conducted a...