Genetic Variation in Immune Regulation and DNA Repair Pathways and Stomach Cancer in China
The incidence of stomach cancer is high in certain parts of the world, particularly in China. Chronic Helicobacter pylori infection is the main risk factor, yet the vast majority of infected individuals remain unaffected with cancer, suggesting an important role of other risk factors. We conducted a...
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| Published in | Cancer epidemiology, biomarkers & prevention Vol. 18; no. 8; pp. 2304 - 2309 |
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| Main Authors | , , , , , , , , , , , , , , , , |
| Format | Journal Article |
| Language | English |
| Published |
Philadelphia, PA
American Association for Cancer Research
01.08.2009
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| Subjects | |
| Online Access | Get full text |
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| Abstract | The incidence of stomach cancer is high in certain parts of the world, particularly in China. Chronic Helicobacter pylori infection is the main risk factor, yet the vast majority of infected individuals remain unaffected with cancer, suggesting
an important role of other risk factors. We conducted a population-based case-control study including 196 incident stomach
cancer cases and 397 matched controls to test the hypothesis that adverse single nucleotide polymorphism (SNP) genotypes and
haplotypes within genes of the DNA repair and immune regulatory pathways are associated with increased stomach cancer risk.
Genomic DNA isolated from blood samples was used for genotyping, and results were obtained for 57 putatively functional SNPs
in 28 genes. Odds ratios (OR) and 95% confidence intervals (95% CI) were obtained from adjusted logistic regression models.
For PTGS2 , a gene involved in the inflammatory response, associations with stomach cancer risk were observed for TC genotype carriers of rs5279 (OR, 0.24; 95% CI, 0.08-0.73), CT genotype carriers of the 3′-untranslated region SNP rs689470 (OR, 7.49; 95% CI, 1.21-46.20), and CTTC haplotype carriers of rs5277, rs5278, rs5279 , and rs689470 (OR, 0.41; 95% CI, 0.18-0.95). For ERCC5 , a gene involved in nucleotide excision repair, TC genotype carriers of rs1047768 (OR, 0.65; 95% CI, 0.41-1.03), GC genotype carriers of the nonsynonymous SNP rs2227869 (OR, 0.30; 95% CI, 0.13-0.67), and CCG haplotype carriers of rs1047768, rs17655 , and rs2227869 (OR, 0.45; 95% CI, 0.20-1.04) were associated with reduced stomach cancer risk. In conclusion, PTGS2 and ERCC5 were associated with stomach cancer risk in a Chinese population. (Cancer Epidemiol Biomarkers Prev 2009;18(8):2304–9) |
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| AbstractList | The incidence of stomach cancer is high in certain parts of the world, particularly in China. Chronic Helicobacter pylori infection is the main risk factor, yet the vast majority of infected individuals remain unaffected with cancer, suggesting an important role of other risk factors. We conducted a population-based case-control study including 196 incident stomach cancer cases and 397 matched controls to test the hypothesis that adverse single nucleotide polymorphism (SNP) genotypes and haplotypes within genes of the DNA repair and immune regulatory pathways are associated with increased stomach cancer risk. Genomic DNA isolated from blood samples was used for genotyping, and results were obtained for 57 putatively functional SNPs in 28 genes. Odds ratios (OR) and 95% confidence intervals (95% CI) were obtained from adjusted logistic regression models. For PTGS2, a gene involved in the inflammatory response, associations with stomach cancer risk were observed for TC genotype carriers of rs5279 (OR, 0.24; 95% CI, 0.08-0.73), CT genotype carriers of the 3'-untranslated region SNP rs689470 (OR, 7.49; 95% CI, 1.21-46.20), and CTTC haplotype carriers of rs5277, rs5278, rs5279, and rs689470 (OR, 0.41; 95% CI, 0.18-0.95). For ERCC5, a gene involved in nucleotide excision repair, TC genotype carriers of rs1047768 (OR, 0.65; 95% CI, 0.41-1.03), GC genotype carriers of the nonsynonymous SNP rs2227869 (OR, 0.30; 95% CI, 0.13-0.67), and CCG haplotype carriers of rs1047768, rs17655, and rs2227869 (OR, 0.45; 95% CI, 0.20-1.04) were associated with reduced stomach cancer risk. In conclusion, PTGS2 and ERCC5 were associated with stomach cancer risk in a Chinese population.The incidence of stomach cancer is high in certain parts of the world, particularly in China. Chronic Helicobacter pylori infection is the main risk factor, yet the vast majority of infected individuals remain unaffected with cancer, suggesting an important role of other risk factors. We conducted a population-based case-control study including 196 incident stomach cancer cases and 397 matched controls to test the hypothesis that adverse single nucleotide polymorphism (SNP) genotypes and haplotypes within genes of the DNA repair and immune regulatory pathways are associated with increased stomach cancer risk. Genomic DNA isolated from blood samples was used for genotyping, and results were obtained for 57 putatively functional SNPs in 28 genes. Odds ratios (OR) and 95% confidence intervals (95% CI) were obtained from adjusted logistic regression models. For PTGS2, a gene involved in the inflammatory response, associations with stomach cancer risk were observed for TC genotype carriers of rs5279 (OR, 0.24; 95% CI, 0.08-0.73), CT genotype carriers of the 3'-untranslated region SNP rs689470 (OR, 7.49; 95% CI, 1.21-46.20), and CTTC haplotype carriers of rs5277, rs5278, rs5279, and rs689470 (OR, 0.41; 95% CI, 0.18-0.95). For ERCC5, a gene involved in nucleotide excision repair, TC genotype carriers of rs1047768 (OR, 0.65; 95% CI, 0.41-1.03), GC genotype carriers of the nonsynonymous SNP rs2227869 (OR, 0.30; 95% CI, 0.13-0.67), and CCG haplotype carriers of rs1047768, rs17655, and rs2227869 (OR, 0.45; 95% CI, 0.20-1.04) were associated with reduced stomach cancer risk. In conclusion, PTGS2 and ERCC5 were associated with stomach cancer risk in a Chinese population. The incidence of stomach cancer is high in certain parts of the world, particularly in China. Chronic Helicobacter pylori infection is the main risk factor, yet the vast majority of infected individuals remain unaffected with cancer, suggesting an important role of other risk factors. We conducted a population-based case-control study including 196 incident stomach cancer cases and 397 matched controls to test the hypothesis that adverse single nucleotide polymorphism (SNP) genotypes and haplotypes within genes of the DNA repair and immune regulatory pathways are associated with increased stomach cancer risk. Genomic DNA isolated from blood samples was used for genotyping, and results were obtained for 57 putatively functional SNPs in 28 genes. Odds ratios (OR) and 95% confidence intervals (95% CI) were obtained from adjusted logistic regression models. For PTGS2, a gene involved in the inflammatory response, associations with stomach cancer risk were observed for TC genotype carriers of rs5279 (OR, 0.24; 95% CI, 0.08-0.73), CT genotype carriers of the 3'-untranslated region SNP rs689470 (OR, 7.49; 95% CI, 1.21-46.20), and CTTC haplotype carriers of rs5277, rs5278, rs5279, and rs689470 (OR, 0.41; 95% CI, 0.18-0.95). For ERCC5, a gene involved in nucleotide excision repair, TC genotype carriers of rs1047768 (OR, 0.65; 95% CI, 0.41-1.03), GC genotype carriers of the nonsynonymous SNP rs2227869 (OR, 0.30; 95% CI, 0.13-0.67), and CCG haplotype carriers of rs1047768, rs17655, and rs2227869 (OR, 0.45; 95% CI, 0.20-1.04) were associated with reduced stomach cancer risk. In conclusion, PTGS2 and ERCC5 were associated with stomach cancer risk in a Chinese population. The incidence of stomach cancer is high in certain parts of the world, particularly in China. Chronic Helicobacter pylori infection is the main risk factor, yet the vast majority of infected individuals remain unaffected with cancer, suggesting an important role of other risk factors. We conducted a population-based case-control study including 196 incident stomach cancer cases and 397 matched controls to test the hypothesis that adverse SNP genotypes and haplotypes within genes of the DNA repair and immune regulatory pathways are associated with increased stomach cancer risk. Genomic DNA isolated from blood samples was used for genotyping, and results were obtained for 57 putatively functional SNPs in 28 genes. Odds ratios (ORs) and 95% confidence intervals (CIs) were obtained from adjusted logistic regression models. For PTGS2, a gene involved in the inflammatory response, associations with stomach cancer risk were observed for TC genotype carriers of rs5279 (OR, 0.24; 95% CI, 0.08–0.73), CT genotype carriers of the 3’ UTR SNP rs689470 (OR, 7.49; 95% CI, 1.21–46.20), and CTTC haplotype carriers of rs5277, rs5278, rs5279, and rs689470 (OR, 0.41; 95% CI, 0.18–0.95). For ERCC5, a gene involved in nucleotide excision repair, TC genotype carriers of rs1047768 (OR, 0.65; 95% CI, 0.41–1.03), GC genotype carriers of the non-synonymous SNP rs2227869 (OR, 0.30; 95% CI, 0.13–0.67), and CCG haplotype carriers of rs1047768, rs17655, rs2227869 (OR, 0.45; 95% CI, 0.20–1.04) were associated with reduced stomach cancer risk. In conclusion, PTGS2 and ERCC5 were associated with stomach cancer risk in a Chinese population. The incidence of stomach cancer is high in certain parts of the world, particularly in China. Chronic Helicobacter pylori infection is the main risk factor, yet the vast majority of infected individuals remain unaffected with cancer, suggesting an important role of other risk factors. We conducted a population-based case-control study including 196 incident stomach cancer cases and 397 matched controls to test the hypothesis that adverse single nucleotide polymorphism (SNP) genotypes and haplotypes within genes of the DNA repair and immune regulatory pathways are associated with increased stomach cancer risk. Genomic DNA isolated from blood samples was used for genotyping, and results were obtained for 57 putatively functional SNPs in 28 genes. Odds ratios (OR) and 95% confidence intervals (95% CI) were obtained from adjusted logistic regression models. For PTGS2, a gene involved in the inflammatory response, associations with stomach cancer risk were observed for TC genotype carriers of rs5279 (OR, 0.24; 95% CI, 0.08-0.73), CT genotype carriers of the 3′-untranslated region SNP rs689470 (OR, 7.49; 95% CI, 1.21-46.20), and CTTC haplotype carriers of rs5277, rs5278, rs5279, and rs689470 (OR, 0.41; 95% CI, 0.18-0.95). For ERCC5, a gene involved in nucleotide excision repair, TC genotype carriers of rs1047768 (OR, 0.65; 95% CI, 0.41-1.03), GC genotype carriers of the nonsynonymous SNP rs2227869 (OR, 0.30; 95% CI, 0.13-0.67), and CCG haplotype carriers of rs1047768, rs17655, and rs2227869 (OR, 0.45; 95% CI, 0.20-1.04) were associated with reduced stomach cancer risk. In conclusion, PTGS2 and ERCC5 were associated with stomach cancer risk in a Chinese population. (Cancer Epidemiol Biomarkers Prev 2009;18(8):2304–9) The incidence of stomach cancer is high in certain parts of the world, particularly in China. Chronic Helicobacter pylori infection is the main risk factor, yet the vast majority of infected individuals remain unaffected with cancer, suggesting an important role of other risk factors. We conducted a population-based case-control study including 196 incident stomach cancer cases and 397 matched controls to test the hypothesis that adverse single nucleotide polymorphism (SNP) genotypes and haplotypes within genes of the DNA repair and immune regulatory pathways are associated with increased stomach cancer risk. Genomic DNA isolated from blood samples was used for genotyping, and results were obtained for 57 putatively functional SNPs in 28 genes. Odds ratios (OR) and 95% confidence intervals (95% CI) were obtained from adjusted logistic regression models. For PTGS2 , a gene involved in the inflammatory response, associations with stomach cancer risk were observed for TC genotype carriers of rs5279 (OR, 0.24; 95% CI, 0.08-0.73), CT genotype carriers of the 3′-untranslated region SNP rs689470 (OR, 7.49; 95% CI, 1.21-46.20), and CTTC haplotype carriers of rs5277, rs5278, rs5279 , and rs689470 (OR, 0.41; 95% CI, 0.18-0.95). For ERCC5 , a gene involved in nucleotide excision repair, TC genotype carriers of rs1047768 (OR, 0.65; 95% CI, 0.41-1.03), GC genotype carriers of the nonsynonymous SNP rs2227869 (OR, 0.30; 95% CI, 0.13-0.67), and CCG haplotype carriers of rs1047768, rs17655 , and rs2227869 (OR, 0.45; 95% CI, 0.20-1.04) were associated with reduced stomach cancer risk. In conclusion, PTGS2 and ERCC5 were associated with stomach cancer risk in a Chinese population. (Cancer Epidemiol Biomarkers Prev 2009;18(8):2304–9) |
| Author | Binh Y. Goldstein Li-Na Mu Yiren Wang Jianyu Rao Jeanette C. Papp Hua Wang Zuo-Feng Zhang Shen-Chih Chang Jin-Kou Zhao Sam S. Oh Bao-Guo Ding Qingwu Jiang Nai-Chieh Y. You Lin Cai Shun-Zhang Yu Shehnaz K. Hussain Sungshim Lani Park |
| AuthorAffiliation | 4 Department of Epidemiology, School of Public Health, Fujian Medical University, Fuzhou, China 6 Fudan University School of Public Health, Shanghai, China 8 Department of Human Genetics, UCLA 5 Taixing City Center for Disease Prevention and Control (CDC), Taixing City, Jiangsu, China 10 Jiangsu Provincial CDC, Nanjing, China 7 Departments of Pathology and Laboratory Medicine, UCLA David Geffen School of Medicine, Los Angeles, CA, USA 1 Department of Epidemiology, University of California, Los Angeles (UCLA) School of Public Health, Los Angeles, CA, USA 2 Jonsson Comprehensive Cancer Center, UCLA, Los Angeles, CA USA 3 Department of Social and Preventive Medicine, State University of New York (SUNY) at Buffalo, NY, USA 9 Gates Foundation Beijing Office, China |
| AuthorAffiliation_xml | – name: 2 Jonsson Comprehensive Cancer Center, UCLA, Los Angeles, CA USA – name: 3 Department of Social and Preventive Medicine, State University of New York (SUNY) at Buffalo, NY, USA – name: 5 Taixing City Center for Disease Prevention and Control (CDC), Taixing City, Jiangsu, China – name: 4 Department of Epidemiology, School of Public Health, Fujian Medical University, Fuzhou, China – name: 7 Departments of Pathology and Laboratory Medicine, UCLA David Geffen School of Medicine, Los Angeles, CA, USA – name: 9 Gates Foundation Beijing Office, China – name: 1 Department of Epidemiology, University of California, Los Angeles (UCLA) School of Public Health, Los Angeles, CA, USA – name: 6 Fudan University School of Public Health, Shanghai, China – name: 10 Jiangsu Provincial CDC, Nanjing, China – name: 8 Department of Human Genetics, UCLA |
| Author_xml | – sequence: 1 givenname: Shehnaz K. surname: Hussain fullname: Hussain, Shehnaz K. – sequence: 2 givenname: Li-Na surname: Mu fullname: Mu, Li-Na – sequence: 3 givenname: Lin surname: Cai fullname: Cai, Lin – sequence: 4 givenname: Shen-Chih surname: Chang fullname: Chang, Shen-Chih – sequence: 5 givenname: Sungshim Lani surname: Park fullname: Park, Sungshim Lani – sequence: 6 givenname: Sam S. surname: Oh fullname: Oh, Sam S. – sequence: 7 givenname: Yiren surname: Wang fullname: Wang, Yiren – sequence: 8 givenname: Binh Y. surname: Goldstein fullname: Goldstein, Binh Y. – sequence: 9 givenname: Bao-Guo surname: Ding fullname: Ding, Bao-Guo – sequence: 10 givenname: Qingwu surname: Jiang fullname: Jiang, Qingwu – sequence: 11 givenname: Jianyu surname: Rao fullname: Rao, Jianyu – sequence: 12 givenname: Nai-Chieh Y. surname: You fullname: You, Nai-Chieh Y. – sequence: 13 givenname: Shun-Zhang surname: Yu fullname: Yu, Shun-Zhang – sequence: 14 givenname: Jeanette C. surname: Papp fullname: Papp, Jeanette C. – sequence: 15 givenname: Jin-Kou surname: Zhao fullname: Zhao, Jin-Kou – sequence: 16 givenname: Hua surname: Wang fullname: Wang, Hua – sequence: 17 givenname: Zuo-Feng surname: Zhang fullname: Zhang, Zuo-Feng |
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| Keywords | Genetic variability Genotype Immune regulation Malignant tumor Stomach cancer DNA repair Cancerology DNA Digestive diseases Genetics Cancer Gastric disease Polymorphism |
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| SubjectTerms | Biological and medical sciences Case-Control Studies China Cyclooxygenase 2 - genetics DNA repair DNA Repair - genetics DNA-Binding Proteins - genetics Endonucleases - genetics Female Gastroenterology. Liver. Pancreas. Abdomen genetic polymorphism Genetic Predisposition to Disease Genotype Haplotypes Humans Immune System Phenomena - genetics inflammation Male Medical sciences Middle Aged Nuclear Proteins - genetics Odds Ratio Polymorphism, Single Nucleotide SNP stomach cancer Stomach Neoplasms - genetics Stomach Neoplasms - immunology Stomach. Duodenum. Small intestine. Colon. Rectum. Anus Transcription Factors - genetics Tumors |
| Title | Genetic Variation in Immune Regulation and DNA Repair Pathways and Stomach Cancer in China |
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