A High-Fat Diet Induces Muscle Mitochondrial Dysfunction and Impairs Swimming Capacity in Zebrafish: A New Model of Sarcopenic Obesity

• Published in: Nutrients Vol. 14; no. 9; p. 1975
• Main Authors: Zou, Yun-Yi, Chen, Zhang-Lin, Sun, Chen-Chen, Yang, Dong, Zhou, Zuo-Qiong, Xiao, Qin, Peng, Xi-Yang, Tang, Chang-Fa
• Format: Journal Article
• Language: English
• Published: Switzerland MDPI AG 09.05.2022; MDPI
• Subjects: Antibodies; Atrophy; Danio rerio; Diabetes; Diet; Epoxy resins; Ethanol; High fat diet; Kinases; Liver; Medical research; Metabolic disorders; Metabolic syndrome; Metabolism; Mitochondria; muscle; Muscles; Musculoskeletal system; Obesity; Oxidation; Proteins; Sarcopenia; sarcopenic obesity; Skeletal muscle; Statistical analysis; Swimming; Transmission electron microscopy; Zebrafish; Denmark; Beijing China; United States > US; China; Japan; zebrafish; sarcopenic obesity; mitochondria; high-fat diet; muscle

Obesity is a highly prevalent disease that can induce metabolic syndrome and is associated with a greater risk of muscular atrophy. Mitochondria play central roles in regulating the physiological metabolism of skeletal muscle; however, whether a decreased mitochondrial function is associated with im...