Roles of PPAR delta in lipid absorption and metabolism: a new target for the treatment of type 2 diabetes

• Published in: Biochimica et biophysica acta Vol. 1740; no. 2; pp. 313 - 317
• Main Authors: Luquet, Serge, Gaudel, Celine, Holst, Dorte, Lopez-Soriano, Joaquin, Jehl-Pietri, Chantal, Fredenrich, Alexandre, Grimaldi, Paul A.
• Format: Journal Article
• Language: English
• Published: Netherlands Elsevier B.V 30.05.2005
• Subjects: Adipose Tissue - metabolism; Animals; Carrier Proteins - metabolism; Diabetes Mellitus, Type 2 - drug therapy; Diabetes Mellitus, Type 2 - metabolism; Fatty acid; Fatty Acid-Binding Proteins; Fatty Acids - metabolism; Humans; Lipid Metabolism; Metabolic syndrome; Metabolic Syndrome - drug therapy; Mitochondrial Trifunctional Protein; Multienzyme Complexes - metabolism; Muscle, Skeletal - metabolism; Obesity; PPAR; PPAR delta - agonists; PPAR delta - metabolism; Type 2 diabetes; Type 2 diabetes; Obesity; PPAR; Metabolic syndrome; Fatty acid

Peroxisome proliferator-activated receptors (PPARs) are lipid-activated transcription factors exerting several functions in development and metabolism. PPARα, activated by polyunsaturated fatty acids and fibrates, is implicated in regulation of lipid metabolism, lipoprotein synthesis and metabolism...