Dissection of Targeting Molecular Mechanisms of Aristolochic Acid-induced Nephrotoxicity via a Combined Deconvolution Strategy of Chemoproteomics and Metabolomics

• Published in: International journal of biological sciences Vol. 18; no. 5; pp. 2003 - 2017
• Main Authors: Zhang, Qian, Luo, Piao, Chen, Jiayun, Yang, Chuanbin, Xia, Fei, Zhang, Junzhe, Tang, Huan, Liu, Dandan, Gu, Liwei, Shi, Qiaoli, He, Xueling, Yang, Tong, Wang, Jigang
• Format: Journal Article
• Language: English
• Published: Australia Ivyspring International Publisher Pty Ltd 01.01.2022; Ivyspring International Publisher
• Subjects: Aerobic respiration; Apoptosis; Aristolochic acid; Aristolochic Acids - toxicity; ATP synthase; Binding; Biological activity; Biosynthesis; Carcinogens; Dehydrogenases; Electron transport; Enzymes; Experiments; Fatty acids; Female; Glucose metabolism; Homeostasis; Humans; Kidney; Kidney diseases; Kidney Diseases - chemically induced; Kinases; Krebs cycle; Labeling; Localization; Male; Metabolism; Metabolites; Metabolomics; Mitochondria; Molecular modelling; Natural products; Nephritis; Nephropathy; Oxidation; Oxygen consumption; Proteins; Proteomics; Research Paper; Respiration; Toxicity; Tricarboxylic acid cycle; Urothelial cancer; apoptosis; chemical proteomics; metabolism; mitochondrial dysfunction; Aristolochic acid nephropathy

Aristolochic acid (AA), mainly derived from herbal and plants, was listed as a human carcinogen class I in 2002. Aristolochic acid nephropathy (AAN) is a rapidly progressive tubulointerstitial nephritis and urothelial cancer caused by AA. However, the targeting molecular mechanisms of AAs-induced ne...