C1ql1/Ctrp14 and C1ql4/Ctrp11 promote angiogenesis of endothelial cells through activation of ERK1/2 signal pathway

• Published in: Molecular and cellular biochemistry Vol. 424; no. 1-2; pp. 57 - 67
• Main Authors: Liu, Fang, Tan, Anni, Yang, Renhao, Xue, Yingzi, Zhang, Ming, Chen, Lei, Xiao, Luanjuan, Yang, Xuesong, Yu, Yanhong
• Format: Journal Article
• Language: English
• Published: New York Springer US 01.01.2017; Springer; Springer Nature B.V
• Subjects: Adipocytes; Adipose tissue; Angiogenesis; Antibodies; Biochemistry; Biomedical and Life Sciences; Brain; Cardiology; Cardiovascular diseases; Complement C1q - pharmacology; Endothelium; Human Umbilical Vein Endothelial Cells; Humans; Life Sciences; MAP Kinase Signaling System - drug effects; Medical Biochemistry; Membranes; Mitogen-Activated Protein Kinase 1 - metabolism; Mitogen-Activated Protein Kinase 3 - metabolism; Neovascularization; Neovascularization, Physiologic - drug effects; Nerve Tissue Proteins - metabolism; Oncology; Protein Domains; Proteins; Von Willebrand factor; C1ql1/Ctrp14; Angiogenesis; Chick yolk sac membrane; ERK1/2; C1ql4/Ctrp11; HUVECs

C1ql-like (C1QL)-1 and -4 proteins are encoded by homologous genes that are highly expressed in brain and adipose tissues. However, functional properties of C1QL proteins outside of the brain and adipocytes remain unknown. Here, we report that the globular domain of C1ql1/Ctrp14 and C1ql4/Ctrp11 pro...