Dysfunction of the Ubiquitin Proteasome and Ubiquitin-Like Systems in Schizophrenia

• Published in: Neuropsychopharmacology (New York, N.Y.) Vol. 38; no. 10; pp. 1910 - 1920
• Main Authors: Rubio, María D, Wood, Krista, Haroutunian, Vahram, Meador-Woodruff, James H
• Format: Journal Article
• Language: English
• Published: Basingstoke Nature Publishing Group 01.09.2013
• Subjects: Adult and adolescent clinical studies; Aged; Aged, 80 and over; Alzheimer's disease; Animals; Biological and medical sciences; Case-Control Studies; Endosomal Sorting Complexes Required for Transport - metabolism; Female; Haloperidol - pharmacology; Humans; Illnesses; Male; Medical sciences; Middle Aged; Molecular Chaperones - metabolism; Nedd4 Ubiquitin Protein Ligases; NEDD8 Protein; Neurobiology; Neurosciences; Original; Parkinson's disease; Pathophysiology; Protein expression; Protein Inhibitors of Activated STAT - metabolism; Protein Processing, Post-Translational; Proteins; Psychiatry; Psychology. Psychoanalysis. Psychiatry; Psychopathology. Psychiatry; Psychoses; Rats; Schizophrenia; Schizophrenia - enzymology; Signal Transduction - drug effects; Sumoylation; Temporal Lobe - enzymology; Ubiquitin - metabolism; Ubiquitin-Activating Enzymes - metabolism; Ubiquitin-Conjugating Enzymes - metabolism; Ubiquitin-Protein Ligase Complexes - metabolism; Ubiquitin-Protein Ligases - metabolism; Ubiquitination - drug effects; Ubiquitins - metabolism; United States > US; Ubiquitin; Multicatalytic endopeptidase complex; E3 ligase; Enzyme; Schizophrenia; Psychosis; Peptidases; Nedd8ylation; El activase; Ligases; Ufmylation; polyubiquitination; Hydrolases; SUMOylation

Protein expression abnormalities have been implicated in the pathophysiology of schizophrenia, but the underlying cause of these changes is not known. We sought to investigate ubiquitin and ubiquitin-like (UBL) systems (SUMOylation, NEDD8ylation, and Ufmylation) as putative mechanisms underlying pro...