Antifungal Thiazolidines: Synthesis and Biological Evaluation of Mycosidine Congeners

• Published in: Pharmaceuticals (Basel, Switzerland) Vol. 15; no. 5; p. 563
• Main Authors: Levshin, Igor B., Simonov, Alexander Y., Lavrenov, Sergey N., Panov, Alexey A., Grammatikova, Natalia E., Alexandrov, Alexander A., Ghazy, Eslam S. M. O., Savin, Nikita A., Gorelkin, Peter V., Erofeev, Alexander S., Polshakov, Vladimir I.
• Format: Journal Article
• Language: English
• Published: Switzerland MDPI AG 01.05.2022; MDPI
• Subjects: antifungal activity; Antifungal agents; Antimicrobial agents; Cancer; Cell cycle; cell wall; Diabetic neuropathy; drug design; Drugs; Enzymes; glucose transport; Pathogens; Phosphatase; Potash; Potassium; thiazolidine-2,4-dione; Tumor necrosis factor-TNF; glucose transport; cell wall; drug design; antifungal activity; thiazolidine-2,4-dione

Novel derivatives of Mycosidine (3,5-substituted thiazolidine-2,4-diones) are synthesized by Knoevenagel condensation and reactions of thiazolidines with chloroformates or halo-acetic acid esters. Furthermore, 5-Arylidene-2,4-thiazolidinediones and their 2-thioxo analogs containing halogen and hydro...