Virological and Immunological Characteristics of Human Cytomegalovirus Infection Associated With Alzheimer Disease

• Published in: The Journal of infectious diseases Vol. 208; no. 4; pp. 564 - 572
• Main Authors: Lurain, Nell S., Hanson, Barbara A., Martinson, Jeffrey, Leurgans, Sue E., Landay, Alan L., Bennett, David A., Schneider, Julie A.
• Format: Journal Article
• Language: English
• Published: Oxford Oxford University Press 15.08.2013
• Subjects: Aged; Aged, 80 and over; Alzheimer Disease - complications; Alzheimer Disease - pathology; Alzheimers disease; Amyloid beta-Peptides - analysis; Antibodies; Antibodies, Viral - blood; Antibodies, Viral - cerebrospinal fluid; Biological and medical sciences; Cerebrospinal fluid; Cytomegalovirus; Cytomegalovirus Infections - complications; Cytomegalovirus Infections - immunology; Cytomegalovirus Infections - virology; Female; Fibroblasts - chemistry; Fibroblasts - virology; Fundamental and applied biological sciences. Psychology; Herpes simplex virus 1; Human cytomegalovirus; Human herpesvirus 1; Humans; Infections; Infectious diseases; Interferon-gamma - cerebrospinal fluid; Major and Brief Reports; Male; Medical sciences; Microbiology; Miscellaneous; Neurofibrillary Tangles - metabolism; Pathology; Phenotypes; T lymphocytes; T-Lymphocyte Subsets - immunology; Viral diseases; Virology; VIRUSES; Virus; Infection; Nervous system diseases; Alzheimer disease; Herpesviridae; Viral disease; Central nervous system disease; Degenerative disease; Betaherpesvirinae; Cerebral disorder; Human cytomegalovirus; amyloid-β; CD28-/CD57+ T cells; cytomegalovirus; Alzheimer's disease; interferon-gamma

Serum, cerebrospinal fluid (CSF), and cryopreserved lymphocytes from subjects in the Rush Alzheimer's Disease Center Religious Orders Study were analyzed for associations between cytomegalovirus (CMV) infection and clinical and pathological markers of Alzheimer disease. CMV antibody levels were...