Insecticide resistance genes affect Culex quinquefasciatus vector competence for West Nile virus

Insecticide resistance has been reported to impact the interactions between mosquitoes and the pathogens they transmit. However, the effect on vector competence for arboviruses still remained to be investigated. We examined the influence of two insecticide resistance mechanisms on vector competence...

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Published inProceedings of the Royal Society. B, Biological sciences Vol. 286; no. 1894; p. 20182273
Main Authors Atyame, Célestine M., Alout, Haoues, Mousson, Laurence, Vazeille, Marie, Diallo, Mawlouth, Weill, Mylène, Failloux, Anna-Bella
Format Journal Article
LanguageEnglish
Published England Royal Society, The 16.01.2019
The Royal Society
Subjects
Animals
Culex - drug effects
Culex - genetics
Culex - virology
Ecology
Feeding Behavior
Female
Genes, Insect
Insecticide Resistance - genetics
Life Sciences
Microbiology and Parasitology
Mosquito Vectors - drug effects
Mosquito Vectors - genetics
Mosquito Vectors - virology
Virology
West Nile Fever - transmission
West Nile virus - physiology
vector competence
insecticide resistance
arboviruses
Culex quinquefasciatus
genetics
microbiology Keywords: insecticide resistance
Subject Category: Ecology Subject Areas: ecology
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Abstract Insecticide resistance has been reported to impact the interactions between mosquitoes and the pathogens they transmit. However, the effect on vector competence for arboviruses still remained to be investigated. We examined the influence of two insecticide resistance mechanisms on vector competence of the mosquito Culex quinquefasciatus for two arboviruses, Rift Valley Fever virus (RVFV) and West Nile virus (WNV). Three Cx. quinquefasciatus lines sharing a common genetic background were used: two insecticide-resistant lines, one homozygous for amplification of the Ester 2 locus (SA2), the other homozygous for the acetylcholinesterase ace-1 G119S mutation (SR) and the insecticide-susceptible reference line Slab. Statistical analyses revealed no significant effect of insecticide-resistant mechanisms on vector competence for RVFV. However, both insecticide resistance mechanisms significantly influenced the outcome of WNV infections by increasing the dissemination of WNV in the mosquito body, therefore leading to an increase in transmission efficiency by resistant mosquitoes. These results showed that insecticide resistance mechanisms enhanced vector competence for WNV and may have a significant impact on transmission dynamics of arboviruses. Our findings highlight the importance of understanding the impacts of insecticide resistance on the vectorial capacity parameters to assess the overall consequence on transmission.
AbstractList Insecticide resistance has been reported to impact the interactions between mosquitoes and the pathogens they transmit. However, the effect on vector competence for arboviruses still remained to be investigated. We examined the influence of two insecticide resistance mechanisms on vector competence of the mosquito Culex quinquefasciatus for two arboviruses, Rift Valley Fever virus (RVFV) and West Nile virus (WNV). Three Cx. quin-quefasciatus lines sharing a common genetic background were used: two insecticide-resistant lines, one homozygous for amplification of the Ester 2 locus (SA2), the other homozygous for the acetylcholinesterase ace-1 G119S mutation (SR) and the insecticide-susceptible reference line Slab. Statistical analyses revealed no significant effect of insecticide-resistant mechanisms on vector competence for RVFV. However, both insecticide resistance mechanisms significantly influenced the outcome of WNV infections by increasing the dissemination of WNV in the mosquito body, therefore leading to an increase in transmission efficiency by resistant mosquitoes. These results showed that insecticide resistance mechanisms enhanced vector competence for WNV and may have a significant impact on transmission dynamics of arboviruses. Our findings highlight the importance of understanding the impacts of insecticide resistance on the vectorial capacity parameters to assess the overall consequence on transmission.
Insecticide resistance has been reported to impact the interactions between mosquitoes and the pathogens they transmit. However, the effect on vector competence for arboviruses still remained to be investigated. We examined the influence of two insecticide resistance mechanisms on vector competence of the mosquito Culex quinquefasciatus for two arboviruses, Rift Valley Fever virus (RVFV) and West Nile virus (WNV). Three Cx. quinquefasciatus lines sharing a common genetic background were used: two insecticide-resistant lines, one homozygous for amplification of the Ester locus (SA2), the other homozygous for the acetylcholinesterase ace-1 G119S mutation (SR) and the insecticide-susceptible reference line Slab. Statistical analyses revealed no significant effect of insecticide-resistant mechanisms on vector competence for RVFV. However, both insecticide resistance mechanisms significantly influenced the outcome of WNV infections by increasing the dissemination of WNV in the mosquito body, therefore leading to an increase in transmission efficiency by resistant mosquitoes. These results showed that insecticide resistance mechanisms enhanced vector competence for WNV and may have a significant impact on transmission dynamics of arboviruses. Our findings highlight the importance of understanding the impacts of insecticide resistance on the vectorial capacity parameters to assess the overall consequence on transmission.
Insecticide resistance has been reported to impact the interactions between mosquitoes and the pathogens they transmit. However, the effect on vector competence for arboviruses still remained to be investigated. We examined the influence of two insecticide resistance mechanisms on vector competence of the mosquito Culex quinquefasciatus for two arboviruses, Rift Valley Fever virus (RVFV) and West Nile virus (WNV). Three Cx. quinquefasciatus lines sharing a common genetic background were used: two insecticide-resistant lines, one homozygous for amplification of the Ester 2 locus (SA2), the other homozygous for the acetylcholinesterase ace-1 G119S mutation (SR) and the insecticide-susceptible reference line Slab. Statistical analyses revealed no significant effect of insecticide-resistant mechanisms on vector competence for RVFV. However, both insecticide resistance mechanisms significantly influenced the outcome of WNV infections by increasing the dissemination of WNV in the mosquito body, therefore leading to an increase in transmission efficiency by resistant mosquitoes. These results showed that insecticide resistance mechanisms enhanced vector competence for WNV and may have a significant impact on transmission dynamics of arboviruses. Our findings highlight the importance of understanding the impacts of insecticide resistance on the vectorial capacity parameters to assess the overall consequence on transmission.
Insecticide resistance has been reported to impact the interactions between mosquitoes and the pathogens they transmit. However, the effect on vector competence for arboviruses still remained to be investigated. We examined the influence of two insecticide resistance mechanisms on vector competence of the mosquito Culex quinquefasciatus for two arboviruses, Rift Valley Fever virus (RVFV) and West Nile virus (WNV). Three Cx. quinquefasciatus lines sharing a common genetic background were used: two insecticide-resistant lines, one homozygous for amplification of the Ester2 locus (SA2), the other homozygous for the acetylcholinesterase ace-1 G119S mutation (SR) and the insecticide-susceptible reference line Slab. Statistical analyses revealed no significant effect of insecticide-resistant mechanisms on vector competence for RVFV. However, both insecticide resistance mechanisms significantly influenced the outcome of WNV infections by increasing the dissemination of WNV in the mosquito body, therefore leading to an increase in transmission efficiency by resistant mosquitoes. These results showed that insecticide resistance mechanisms enhanced vector competence for WNV and may have a significant impact on transmission dynamics of arboviruses. Our findings highlight the importance of understanding the impacts of insecticide resistance on the vectorial capacity parameters to assess the overall consequence on transmission.Insecticide resistance has been reported to impact the interactions between mosquitoes and the pathogens they transmit. However, the effect on vector competence for arboviruses still remained to be investigated. We examined the influence of two insecticide resistance mechanisms on vector competence of the mosquito Culex quinquefasciatus for two arboviruses, Rift Valley Fever virus (RVFV) and West Nile virus (WNV). Three Cx. quinquefasciatus lines sharing a common genetic background were used: two insecticide-resistant lines, one homozygous for amplification of the Ester2 locus (SA2), the other homozygous for the acetylcholinesterase ace-1 G119S mutation (SR) and the insecticide-susceptible reference line Slab. Statistical analyses revealed no significant effect of insecticide-resistant mechanisms on vector competence for RVFV. However, both insecticide resistance mechanisms significantly influenced the outcome of WNV infections by increasing the dissemination of WNV in the mosquito body, therefore leading to an increase in transmission efficiency by resistant mosquitoes. These results showed that insecticide resistance mechanisms enhanced vector competence for WNV and may have a significant impact on transmission dynamics of arboviruses. Our findings highlight the importance of understanding the impacts of insecticide resistance on the vectorial capacity parameters to assess the overall consequence on transmission.
Author Failloux, Anna-Bella
Alout, Haoues
Atyame, Célestine M.
Mousson, Laurence
Vazeille, Marie
Weill, Mylène
Diallo, Mawlouth
AuthorAffiliation 1 Department of Virology, Institut Pasteur, Arboviruses and Insect Vectors , Paris , France
4 Institut des Sciences de l'Evolution de Montpellier (ISEM), UMR CNRS-IRD-EPHE-Université de Montpellier , Montpellier , France
3 INRA, UMR 1309 ASTRE, INRA-CIRAD , 34598 Montpellier , France
2 Université de La Réunion, UMR PIMIT (Processus Infectieux en Milieu Insulaire Tropical) CNRS-INSERM-IRD-Université de La Réunion , île de La Réunion , France
5 Institut Pasteur de Dakar, Unité d'Entomologie médicale , Dakar , Sénégal
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Cites_doi 10.1023/A:1013300108134
10.1186/1756-3305-7-437
10.1016/j.onehlt.2017.06.001
10.1186/s13071-016-1383-y
10.1093/jmedent/47.5.884
10.1038/423136b
10.1186/1475-2875-9-168
10.1186/1297-9716-44-78
10.1038/hdy.2009.100
10.1371/journal.pone.0005895
10.1016/j.coviro.2015.08.011
10.1111/mec.14463
10.1111/j.0014-3820.2004.tb01680.x
10.1046/j.1365-2583.1998.72062.x
10.1111/mec.13855
10.1089/vbz.2009.0246
10.1017/S0016672304006792
10.1046/j.1365-2583.2000.00164.x
10.1111/j.0014-3820.2006.tb01108.x
10.1002/1526-4998(200009)56:9<727::AID-PS214>3.0.CO;2-I
10.1016/0169-4758(88)90083-X
10.1098/rspb.2002.2022
10.1016/j.cub.2004.07.008
10.1074/jbc.M705873200
10.1016/j.cois.2017.05.002
10.1186/s12936-015-0924-8
10.1111/j.0014-3820.2004.tb01579.x
10.1111/j.1365-2583.2007.00728.x
10.18637/jss.v069.i01
10.1038/23685
10.1073/pnas.1116932108
10.1111/j.1365-2583.2005.00582.x
10.1111/j.1420-9101.2005.00938.x
10.1089/vbz.2008.0009
10.1603/ME10121
10.1371/journal.pone.0063849
10.1093/infdis/jiu276
10.3390/v7072795
10.1038/s41598-018-20367-4
10.2987/08-5791.1
10.1146/annurev.ento.45.1.449
10.1017/S001667230100547X
10.1371/journal.ppat.1000098
10.3201/eid0704.017417
10.1186/1475-2875-9-379
10.1186/s12936-016-1331-5
10.1016/S0965-1748(02)00097-8
10.1186/1756-3305-6-184
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Keywords vector competence
insecticide resistance
arboviruses
Culex quinquefasciatus
genetics
microbiology Keywords: insecticide resistance
Subject Category: Ecology Subject Areas: ecology
Language English
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References e_1_3_7_20_2
e_1_3_7_43_2
e_1_3_7_22_2
e_1_3_7_41_2
e_1_3_7_24_2
e_1_3_7_47_2
e_1_3_7_26_2
e_1_3_7_45_2
e_1_3_7_28_2
e_1_3_7_49_2
Labbe P (e_1_3_7_6_2) 2017
e_1_3_7_51_2
e_1_3_7_30_2
e_1_3_7_11_2
e_1_3_7_13_2
e_1_3_7_34_2
e_1_3_7_15_2
e_1_3_7_36_2
e_1_3_7_17_2
e_1_3_7_38_2
e_1_3_7_19_2
e_1_3_7_2_2
e_1_3_7_4_2
e_1_3_7_8_2
e_1_3_7_40_2
e_1_3_7_44_2
e_1_3_7_21_2
e_1_3_7_42_2
e_1_3_7_23_2
e_1_3_7_48_2
e_1_3_7_25_2
e_1_3_7_46_2
e_1_3_7_27_2
e_1_3_7_29_2
e_1_3_7_9_2
R Core Team (e_1_3_7_31_2) 2017
e_1_3_7_50_2
Fox J (e_1_3_7_32_2) 2011
e_1_3_7_10_2
e_1_3_7_33_2
e_1_3_7_52_2
e_1_3_7_12_2
e_1_3_7_35_2
e_1_3_7_14_2
e_1_3_7_37_2
e_1_3_7_16_2
e_1_3_7_39_2
e_1_3_7_18_2
e_1_3_7_3_2
e_1_3_7_5_2
e_1_3_7_7_2
References_xml – ident: e_1_3_7_4_2
  doi: 10.1023/A:1013300108134
– ident: e_1_3_7_43_2
  doi: 10.1186/1756-3305-7-437
– ident: e_1_3_7_2_2
  doi: 10.1016/j.onehlt.2017.06.001
– ident: e_1_3_7_28_2
  doi: 10.1186/s13071-016-1383-y
– ident: e_1_3_7_35_2
  doi: 10.1093/jmedent/47.5.884
– ident: e_1_3_7_9_2
  doi: 10.1038/423136b
– ident: e_1_3_7_20_2
  doi: 10.1186/1475-2875-9-168
– start-page: 449
  volume-title: An R companion to applied regression
  year: 2011
  ident: e_1_3_7_32_2
– ident: e_1_3_7_36_2
  doi: 10.1186/1297-9716-44-78
– ident: e_1_3_7_19_2
  doi: 10.1038/hdy.2009.100
– ident: e_1_3_7_30_2
  doi: 10.1371/journal.pone.0005895
– ident: e_1_3_7_52_2
  doi: 10.1016/j.coviro.2015.08.011
– ident: e_1_3_7_15_2
  doi: 10.1111/mec.14463
– ident: e_1_3_7_13_2
  doi: 10.1111/j.0014-3820.2004.tb01680.x
– ident: e_1_3_7_7_2
  doi: 10.1046/j.1365-2583.1998.72062.x
– ident: e_1_3_7_17_2
  doi: 10.1111/mec.13855
– ident: e_1_3_7_40_2
  doi: 10.1089/vbz.2009.0246
– ident: e_1_3_7_11_2
  doi: 10.1017/S0016672304006792
– ident: e_1_3_7_50_2
  doi: 10.1046/j.1365-2583.2000.00164.x
– ident: e_1_3_7_14_2
  doi: 10.1111/j.0014-3820.2006.tb01108.x
– ident: e_1_3_7_26_2
  doi: 10.1002/1526-4998(200009)56:9<727::AID-PS214>3.0.CO;2-I
– ident: e_1_3_7_3_2
  doi: 10.1016/0169-4758(88)90083-X
– ident: e_1_3_7_18_2
  doi: 10.1098/rspb.2002.2022
– ident: e_1_3_7_27_2
  doi: 10.1016/j.cub.2004.07.008
– ident: e_1_3_7_46_2
  doi: 10.1074/jbc.M705873200
– ident: e_1_3_7_34_2
  doi: 10.1016/j.cois.2017.05.002
– ident: e_1_3_7_44_2
  doi: 10.1186/s12936-015-0924-8
– start-page: 686
  volume-title: Genetics and evolution of infectious diseases
  year: 2017
  ident: e_1_3_7_6_2
– ident: e_1_3_7_12_2
  doi: 10.1111/j.0014-3820.2004.tb01579.x
– ident: e_1_3_7_49_2
  doi: 10.1111/j.1365-2583.2007.00728.x
– ident: e_1_3_7_33_2
  doi: 10.18637/jss.v069.i01
– ident: e_1_3_7_16_2
  doi: 10.1038/23685
– ident: e_1_3_7_47_2
  doi: 10.1073/pnas.1116932108
– ident: e_1_3_7_48_2
  doi: 10.1111/j.1365-2583.2005.00582.x
– ident: e_1_3_7_5_2
  doi: 10.1111/j.1420-9101.2005.00938.x
– ident: e_1_3_7_37_2
  doi: 10.1089/vbz.2008.0009
– ident: e_1_3_7_45_2
  doi: 10.1603/ME10121
– ident: e_1_3_7_23_2
  doi: 10.1371/journal.pone.0063849
– ident: e_1_3_7_24_2
  doi: 10.1093/infdis/jiu276
– volume-title: R: a language and environment for statistical computing
  year: 2017
  ident: e_1_3_7_31_2
– ident: e_1_3_7_38_2
  doi: 10.3390/v7072795
– ident: e_1_3_7_21_2
  doi: 10.1038/s41598-018-20367-4
– ident: e_1_3_7_39_2
  doi: 10.2987/08-5791.1
– ident: e_1_3_7_8_2
  doi: 10.1146/annurev.ento.45.1.449
– ident: e_1_3_7_10_2
  doi: 10.1017/S001667230100547X
– ident: e_1_3_7_51_2
  doi: 10.1371/journal.ppat.1000098
– ident: e_1_3_7_29_2
  doi: 10.3201/eid0704.017417
– ident: e_1_3_7_42_2
  doi: 10.1186/1475-2875-9-379
– ident: e_1_3_7_25_2
  doi: 10.1186/s12936-016-1331-5
– ident: e_1_3_7_22_2
  doi: 10.1016/S0965-1748(02)00097-8
– ident: e_1_3_7_41_2
  doi: 10.1186/1756-3305-6-184
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Snippet Insecticide resistance has been reported to impact the interactions between mosquitoes and the pathogens they transmit. However, the effect on vector...
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StartPage 20182273
SubjectTerms Animals
Culex - drug effects
Culex - genetics
Culex - virology
Ecology
Feeding Behavior
Female
Genes, Insect
Insecticide Resistance - genetics
Life Sciences
Microbiology and Parasitology
Mosquito Vectors - drug effects
Mosquito Vectors - genetics
Mosquito Vectors - virology
Virology
West Nile Fever - transmission
West Nile virus - physiology
Title Insecticide resistance genes affect Culex quinquefasciatus vector competence for West Nile virus
URI https://www.ncbi.nlm.nih.gov/pubmed/30963855
https://www.proquest.com/docview/2206229441
https://pasteur.hal.science/pasteur-02098394
https://pubmed.ncbi.nlm.nih.gov/PMC6367175
Volume 286
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