Docosahexaenoic acid-concentrated fish oil supplementation in subjects with mild cognitive impairment (MCI): a 12-month randomised, double-blind, placebo-controlled trial

• Published in: Psychopharmacology Vol. 225; no. 3; pp. 605 - 612
• Main Authors: Lee, Lai Kuan, Shahar, Suzana, Chin, Ai-Vyrn, Yusoff, Noor Aini Mohd
• Format: Journal Article
• Language: English
• Published: Berlin/Heidelberg Springer-Verlag 01.02.2013; Springer; Springer Nature B.V
• Subjects: Aged; Alzheimer's disease; Analysis of Variance; Biomedical and Life Sciences; Biomedicine; Cognition & reasoning; Cognition - drug effects; Cognition disorders; Cognition Disorders - drug therapy; Cognition Disorders - psychology; Dietary Supplements; Docosahexaenoic Acids - chemistry; Docosahexaenoic Acids - therapeutic use; Double-Blind Method; Drug therapy; Female; Fish oils; Fish Oils - chemistry; Fish Oils - therapeutic use; Health aspects; Humans; Male; Memory; Memory, Short-Term - drug effects; Middle Aged; Neurosciences; Original Investigation; Pharmacology/Toxicology; Psychiatry; Psychomotor Performance - drug effects; Psychopharmacology; Severity of Illness Index; Socioeconomic Factors; Treatment Outcome; Malaysia; Docosahexaenoic acid; Cognitive function; Mild cognitive impairment; Fish oil; Memory

Rationale Epidemiological studies have suggested a beneficial effect of fish oil supplementation in halting the initial progression of Alzheimer’s disease. However, it remains unclear whether fish oil affects cognitive function in older people with mild cognitive impairment (MCI). Objectives This st...