Chronic dry eye disease is principally mediated by effector memory Th17 cells

• Published in: Mucosal immunology Vol. 7; no. 1; pp. 38 - 45
• Main Authors: Chen, Y, Chauhan, S K, Lee, H Soo, Saban, D R, Dana, R
• Format: Journal Article
• Language: English
• Published: United States Nature Publishing Group 01.01.2014
• Subjects: Adoptive Transfer; Animals; Chronic Disease; Disease Models, Animal; Dry Eye Syndromes - immunology; Dry Eye Syndromes - metabolism; Eye - immunology; Eye - metabolism; Eye - pathology; Female; Humans; Immunologic Memory; Inflammation - immunology; Inflammation - metabolism; Mice; T-Lymphocyte Subsets - immunology; T-Lymphocyte Subsets - metabolism; Th17 Cells - immunology; Th17 Cells - metabolism

Recent experimental and clinical data suggest that there is a link between dry eye disease (DED) and T-cell-mediated immunity. However, whether these immune responses are a consequence or cause of ocular surface inflammation remains to be determined. Thus far, only models of acute DED have been used...