Carrageenan-Based Acyclovir Mucoadhesive Vaginal Tablets for Prevention of Genital Herpes

Women are the most affected by genital herpes, which is one of the most common sexually transmitted infections, affecting more than 400 million people worldwide. The application of vaginal microbicides could provide a safe method of protection. Acyclovir is a safe and effective medication for vagina...

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Published inMarine drugs Vol. 18; no. 5; p. 249
Main Authors Pacheco-Quito, Edisson-Mauricio, Ruiz-Caro, Roberto, Rubio, Juan, Tamayo, Aitana, Veiga, María-Dolores
Format Journal Article
LanguageEnglish
Published Switzerland MDPI AG 11.05.2020
MDPI
Subjects
Acyclovir
Acyclovir - administration & dosage
Acyclovir - pharmacokinetics
acyclovir controlled release
Adhesiveness
Administration, Intravaginal
Antiviral Agents - administration & dosage
Antiviral Agents - chemistry
Antiviral Agents - pharmacokinetics
Antiviral drugs
Carrageenan
Carrageenan - chemistry
Controlled release
Delayed-Action Preparations - administration & dosage
Delayed-Action Preparations - pharmacokinetics
Drug delivery systems
Drug Liberation
Excipients - chemistry
Female
Gels
genital herpes
Herpes Genitalis - prevention & control
Herpes Genitalis - virology
Herpes simplex
Herpes viruses
Human papillomavirus
Humans
hydroxypropyl methylcellulose
Hypromellose Derivatives - chemistry
iota-carrageenan
Lesions
marine polymers
Methylcellulose
Microbicides
mucoadhesive vaginal tablets
Mucous Membrane - metabolism
Polymers
Prevention
Sexually transmitted diseases
Spectrum analysis
STD
Tablets
Uptake
Vagina
Vagina - metabolism
Vaginal Creams, Foams, and Jellies - administration & dosage
Vaginal Creams, Foams, and Jellies - chemistry
Vaginal Creams, Foams, and Jellies - pharmacokinetics
Women
Womens health
hydroxypropyl methylcellulose
genital herpes
iota-carrageenan
marine polymers
mucoadhesive vaginal tablets
acyclovir controlled release
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Abstract Women are the most affected by genital herpes, which is one of the most common sexually transmitted infections, affecting more than 400 million people worldwide. The application of vaginal microbicides could provide a safe method of protection. Acyclovir is a safe and effective medication for vaginal administration, and numerous benefits have been observed in the treatment of primary or recurrent lesions due to genital herpes. Vaginal tablets based on a combination of the polymers iota-carrageenan and hydroxypropyl methylcellulose were developed for the controlled release of acyclovir. Swelling, mucoadhesion and drug release studies were carried out in simulated vaginal fluid. The tablets, containing a combination of iota-carrageenan and hydroxypropyl methylcellulose, have an adequate uptake of the medium that allows them to develop the precise consistency and volume of gel for the controlled release of acyclovir. Its high mucoadhesive capacity also allows the formulation to remain in the vaginal area long enough to ensure the complete release of acyclovir. These promising formulations for the prevention of genital herpes deserve further evaluation.
AbstractList Women are the most affected by genital herpes, which is one of the most common sexually transmitted infections, affecting more than 400 million people worldwide. The application of vaginal microbicides could provide a safe method of protection. Acyclovir is a safe and effective medication for vaginal administration, and numerous benefits have been observed in the treatment of primary or recurrent lesions due to genital herpes. Vaginal tablets based on a combination of the polymers iota-carrageenan and hydroxypropyl methylcellulose were developed for the controlled release of acyclovir. Swelling, mucoadhesion and drug release studies were carried out in simulated vaginal fluid. The tablets, containing a combination of iota-carrageenan and hydroxypropyl methylcellulose, have an adequate uptake of the medium that allows them to develop the precise consistency and volume of gel for the controlled release of acyclovir. Its high mucoadhesive capacity also allows the formulation to remain in the vaginal area long enough to ensure the complete release of acyclovir. These promising formulations for the prevention of genital herpes deserve further evaluation.
Author Pacheco-Quito, Edisson-Mauricio
Ruiz-Caro, Roberto
Rubio, Juan
Tamayo, Aitana
Veiga, María-Dolores
AuthorAffiliation 2 Institute of Ceramics and Glass, Spanish National Research Council, CSIC, 28049 Madrid, Spain; jrubio@icv.csic.es (J.R.); aitanath@icv.csic.es (A.T.)
1 Department of Pharmaceutics and Food Technology, Faculty of Pharmacy, Complutense University of Madrid, 28040 Madrid, Spain; edissonp@ucm.es (E.-M.P.-Q.); mdveiga@ucm.es (M.-D.V.)
AuthorAffiliation_xml – name: 1 Department of Pharmaceutics and Food Technology, Faculty of Pharmacy, Complutense University of Madrid, 28040 Madrid, Spain; edissonp@ucm.es (E.-M.P.-Q.); mdveiga@ucm.es (M.-D.V.)
– name: 2 Institute of Ceramics and Glass, Spanish National Research Council, CSIC, 28049 Madrid, Spain; jrubio@icv.csic.es (J.R.); aitanath@icv.csic.es (A.T.)
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  organization: Department of Pharmaceutics and Food Technology, Faculty of Pharmacy, Complutense University of Madrid, 28040 Madrid, Spain
– sequence: 2
  givenname: Roberto
  surname: Ruiz-Caro
  fullname: Ruiz-Caro, Roberto
  organization: Department of Pharmaceutics and Food Technology, Faculty of Pharmacy, Complutense University of Madrid, 28040 Madrid, Spain
– sequence: 3
  givenname: Juan
  surname: Rubio
  fullname: Rubio, Juan
  organization: Institute of Ceramics and Glass, Spanish National Research Council, CSIC, 28049 Madrid, Spain
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  orcidid: 0000-0002-9828-3461
  surname: Tamayo
  fullname: Tamayo, Aitana
  organization: Institute of Ceramics and Glass, Spanish National Research Council, CSIC, 28049 Madrid, Spain
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  givenname: María-Dolores
  surname: Veiga
  fullname: Veiga, María-Dolores
  organization: Department of Pharmaceutics and Food Technology, Faculty of Pharmacy, Complutense University of Madrid, 28040 Madrid, Spain
BackLink https://www.ncbi.nlm.nih.gov/pubmed/32403219$$D View this record in MEDLINE/PubMed
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Issue 5
Keywords hydroxypropyl methylcellulose
genital herpes
iota-carrageenan
marine polymers
mucoadhesive vaginal tablets
acyclovir controlled release
Language English
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SSID ssj0035894
Score 2.430038
Snippet Women are the most affected by genital herpes, which is one of the most common sexually transmitted infections, affecting more than 400 million people...
SourceID doaj
pubmedcentral
proquest
crossref
pubmed
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Open Access Repository
Aggregation Database
Index Database
StartPage 249
SubjectTerms Acyclovir
Acyclovir - administration & dosage
Acyclovir - pharmacokinetics
acyclovir controlled release
Adhesiveness
Administration, Intravaginal
Antiviral Agents - administration & dosage
Antiviral Agents - chemistry
Antiviral Agents - pharmacokinetics
Antiviral drugs
Carrageenan
Carrageenan - chemistry
Controlled release
Delayed-Action Preparations - administration & dosage
Delayed-Action Preparations - pharmacokinetics
Drug delivery systems
Drug Liberation
Excipients - chemistry
Female
Gels
genital herpes
Herpes Genitalis - prevention & control
Herpes Genitalis - virology
Herpes simplex
Herpes viruses
Human papillomavirus
Humans
hydroxypropyl methylcellulose
Hypromellose Derivatives - chemistry
iota-carrageenan
Lesions
marine polymers
Methylcellulose
Microbicides
mucoadhesive vaginal tablets
Mucous Membrane - metabolism
Polymers
Prevention
Sexually transmitted diseases
Spectrum analysis
STD
Tablets
Uptake
Vagina
Vagina - metabolism
Vaginal Creams, Foams, and Jellies - administration & dosage
Vaginal Creams, Foams, and Jellies - chemistry
Vaginal Creams, Foams, and Jellies - pharmacokinetics
Women
Womens health
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Title Carrageenan-Based Acyclovir Mucoadhesive Vaginal Tablets for Prevention of Genital Herpes
URI https://www.ncbi.nlm.nih.gov/pubmed/32403219
https://www.proquest.com/docview/2403817757/abstract/
https://pubmed.ncbi.nlm.nih.gov/PMC7281190
https://doaj.org/article/c283028d11e548c9a37bf48b45f6112d
Volume 18
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