Levodopa impairs probabilistic reversal learning in healthy young adults

• Published in: Psychopharmacology Vol. 233; no. 14; pp. 2753 - 2763
• Main Authors: Vo, Andrew, Seergobin, Ken N., Morrow, Sarah A., MacDonald, Penny A.
• Format: Journal Article
• Language: English
• Published: Berlin/Heidelberg Springer Berlin Heidelberg 01.07.2016; Springer; Springer Nature B.V
• Subjects: Adult; Analysis of Variance; Biomedical and Life Sciences; Biomedicine; Brain - drug effects; Cognition & reasoning; Cognition - drug effects; Cross-Over Studies; Dopamine; Dopamine Agents - pharmacology; Dosage and administration; Double-Blind Method; Drug interactions; Drug therapy; Female; Health aspects; Humans; L-dopa; Learning; Levodopa - administration & dosage; Levodopa - pharmacology; Male; Neurosciences; Observations; Original Investigation; Parkinson Disease - drug therapy; Parkinson's disease; Pharmacology/Toxicology; Psychiatry; Reversal Learning - drug effects; Reward; Young Adult; Learning; Punishment; Striatum; Dopamine; Cognition; Levodopa; Reward; Parkinson’s disease

Rationale Dopaminergic therapy improves some cognitive functions and worsens others in patients with Parkinson’s disease (PD). These paradoxical effects are explained by the dopamine overdose hypothesis, which proposes that effects of dopaminergic therapy on a cognitive function is determined by the...