Maltodextrin-induced intestinal injury in a neonatal mouse model

• Published in: Disease models & mechanisms Vol. 13; no. 8
• Main Authors: Singh, Pratibha, Sanchez-Fernandez, Lady Leidy, Ramiro-Cortijo, David, Ochoa-Allemant, Pedro, Perides, George, Liu, Yan, Medina-Morales, Esli, Yakah, William, Freedman, Steven D, Martin, Camilia R
• Format: Journal Article
• Language: English
• Published: England The Company of Biologists Ltd 27.08.2020; The Company of Biologists
• Subjects: Animals; Animals, Newborn; Baby foods; Carbohydrates; Cytokines - metabolism; Disease Models, Animal; Enterocolitis, Necrotizing - chemically induced; Enterocolitis, Necrotizing - metabolism; Enterocolitis, Necrotizing - microbiology; Enterocolitis, Necrotizing - pathology; Gastrointestinal diseases; Goblet Cells - metabolism; Goblet Cells - microbiology; Goblet Cells - pathology; Hypoxia; Hypoxia - complications; Inflammation Mediators - metabolism; intestinal injury; Intestinal Mucosa - metabolism; Intestinal Mucosa - microbiology; Intestinal Mucosa - pathology; Intestine, Small - metabolism; Intestine, Small - microbiology; Intestine, Small - pathology; Klebsiella pneumoniae; Klebsiella pneumoniae - pathogenicity; Large intestine; maltodextrin; Mice, Inbred C57BL; Microvilli - pathology; Mortality; Mucin-2 - metabolism; Necrosis; necrotizing enterocolitis; neonatal mouse model; Newborn babies; Pathogenesis; Permeability; Polysaccharides; Premature babies; Small intestine; Tight Junction Proteins - metabolism; Necrotizing enterocolitis; Intestinal injury; Neonatal mouse model; Maltodextrin

Prematurity and enteral feedings are major risk factors for intestinal injury leading to necrotizing enterocolitis (NEC). An immature digestive system can lead to maldigestion of macronutrients and increased vulnerability to intestinal injury. The aim of this study was to test in neonatal mice the e...