Adipose mesenchymal stem cell-derived exosomes accelerate skin wound healing via the lncRNA H19/miR-19b/SOX9 axis

• Published in: Laboratory investigation Vol. 101; no. 9; pp. 1254 - 1266
• Main Authors: Qian, Li, Pi, Li, Fang, Bai-Rong, Meng, Xian-Xi
• Format: Journal Article
• Language: English
• Published: New York Elsevier Inc 01.09.2021; Nature Publishing Group US; Nature Publishing Group
• Subjects: 42/100; 631/80; 692/308/2171; Adipose Tissue - cytology; Animals; Assaying; Binding sites; Cell growth; Cell Line; Cell migration; Cell proliferation; Cells, Cultured; Cholecystokinin; Collagen; Electron microscopy; Evaluation; Exosomes; Exosomes - chemistry; Exosomes - metabolism; Fibroblasts; Flow cytometry; Humans; Laboratory Medicine; Male; Medicine; Medicine & Public Health; Mesenchymal stem cells; Mesenchymal Stem Cells - cytology; Mice; Mice, Inbred BALB C; MicroRNAs - metabolism; miRNA; Non-coding RNA; Paracrine signalling; Pathology; Reporter gene; Ribonucleic acid; RNA; RNA, Long Noncoding - metabolism; Signal Transduction - physiology; Skin; Skin - metabolism; Sox9 protein; SOX9 Transcription Factor - metabolism; Stem cell transplantation; Stem cells; Tissues; Western blotting; Wnt protein; Wound healing; Wound Healing - physiology; β-Catenin

It has been reported that adipose mesenchymal stem cells (ADSCs) accelerate wound healing. Moreover, exosomes, which serve as paracrine factors, play a vital role in wound healing. However, the mechanism remains unclear. This research aimed to determine the roles of exosomes derived from ADSCs (ADSC...