Protein-Amino Acid Metabolism Disarrangements: The Hidden Enemy of Chronic Age-Related Conditions

• Published in: Nutrients Vol. 10; no. 4; p. 391
• Main Authors: Pasini, Evasio, Corsetti, Giovanni, Aquilani, Roberto, Romano, Claudia, Picca, Anna, Calvani, Riccardo, Dioguardi, Francesco Saverio
• Format: Journal Article
• Language: English
• Published: Switzerland MDPI AG 22.03.2018; MDPI
• Subjects: Age Factors; Aging - metabolism; Amino Acids - administration & dosage; Amino Acids - metabolism; Anemia; Animals; Biochemistry; Carbohydrates; Catabolism; Compartmentation; Dietary Proteins - administration & dosage; Dietary Proteins - metabolism; Dietary Supplements; Energy Metabolism; Humans; Intermediates; Lipids; Metabolism; Molecular chains; Morbidity; Muscle, Skeletal - metabolism; Muscle, Skeletal - physiopathology; Nutritional Status; Protein biosynthesis; Protein synthesis; Protein turnover; Protein-Losing Enteropathies - diet therapy; Protein-Losing Enteropathies - metabolism; Protein-Losing Enteropathies - physiopathology; Proteins; Proteolysis; Review; Sarcopenia; Sarcopenia - diet therapy; Sarcopenia - metabolism; Sarcopenia - physiopathology; catabolism; inflammation; protein metabolism; muscle wasting; amino acids; sarcopenia

Proteins are macro-molecules crucial for cell life, which are made up of amino acids (AAs). In healthy people, protein synthesis and degradation are well balanced. However, in the presence of hypercatabolic stimulation (i.e., inflammation), protein breakdown increases as the resulting AAs are consum...