Latent Tuberculosis Infection Treatment and T-Cell Responses to Mycobacterium tuberculosis-specific Antigens

• Published in: American journal of respiratory and critical care medicine Vol. 175; no. 3; pp. 282 - 287
• Main Authors: Chee, Cynthia B. E, KhinMar, Kyi W, Gan, Suay H, Barkham, Timothy M. S, Pushparani, Mariappan, Wang, Yee T
• Format: Journal Article
• Language: English
• Published: New York, NY Am Thoracic Soc 01.02.2007; American Lung Association; American Thoracic Society
• Subjects: Adolescent; Adult; Aged; Anesthesia. Intensive care medicine. Transfusions. Cell therapy and gene therapy; Antigens; Antigens, Bacterial - drug effects; Antigens, Bacterial - immunology; Antigens, Bacterial - pharmacology; Bacterial Proteins - immunology; Bacterial Proteins - pharmacology; Biological and medical sciences; Blood. Blood and plasma substitutes. Blood products. Blood cells. Blood typing. Plasmapheresis. Apheresis; Bone marrow, stem cells transplantation. Graft versus host reaction; Cohort Studies; Female; Humans; Immunoassay; Infections; Intensive care medicine; Interferon; Interferon-gamma - analysis; Interferon-gamma - metabolism; Lymphocytes; Male; Medical sciences; Middle Aged; Mycobacterium; Mycobacterium tuberculosis; Peptides; Peptides - immunology; Peptides - pharmacology; Proteins; T-Lymphocytes - drug effects; T-Lymphocytes - immunology; Transfusions. Complications. Transfusion reactions. Cell and gene therapy; Treatment Outcome; Tuberculosis; Tuberculosis, Pulmonary - drug therapy; Tuberculosis, Pulmonary - immunology; Singapore; Intensive care; Cytokine; culture filtrate protein 10; early secretory antigenic target 6-kD protein; Infection; Treatment; T-SPOT.TB; Mycobacterium tuberculosis; Mycobacteriales; T-Lymphocyte; Mycobacteriaceae; Bacteria; Actinomycetes; Antituberculous agent; Interferon; Antibacterial agent; Isoniazid; interferon-γ responses; Resuscitation

There is currently no available test for monitoring the effect of treatment of latent tuberculosis infection (LTBI) to indicate cure or predict risk of subsequent progression to disease. We used the T-SPOT.TB assay, which measures T-cell interferon-gamma responses to the Mycobacterium tuberculosis-s...