Intraindividual Variability in Absolute Bioavailability and Clearance of Midazolam in Healthy Individuals

• Published in: Clinical pharmacokinetics Vol. 62; no. 7; pp. 981 - 987
• Main Authors: Kvitne, Kine Eide, Drevland, Ole Martin, Haugli, Nora, Skadberg, Eline, Zaré, Hasse Khiabani, Åsberg, Anders, Robertsen, Ida
• Format: Journal Article
• Language: English
• Published: Cham Springer International Publishing 01.07.2023; Ovid
• Subjects: Administration, Intravenous; Administration, Oral; Biological Availability; Cytochrome P-450 CYP3A - metabolism; Female; Humans; Internal Medicine; Male; Medicine; Medicine & Public Health; Midazolam; Obesity; Original; Original Research Article; Pharmacology/Toxicology; Pharmacotherapy

Background and Objective Midazolam is the preferred clinical probe drug for assessing CYP3A activity. We have previously shown substantial intraindividual variability in midazolam absolute bioavailability and clearance in patients with obesity before and after weight loss induced by gastric bypass o...