Identification of structurally diverse FSP1 inhibitors that sensitize cancer cells to ferroptosis

• Published in: Cell chemical biology Vol. 30; no. 9; pp. 1090 - 1103.e7
• Main Authors: Hendricks, Joseph M., Doubravsky, Cody E., Wehri, Eddie, Li, Zhipeng, Roberts, Melissa A., Deol, Kirandeep K., Lange, Mike, Lasheras-Otero, Irene, Momper, Jeremiah D., Dixon, Scott J., Bersuker, Kirill, Schaletzky, Julia, Olzmann, James A.
• Format: Journal Article
• Language: English
• Published: United States Elsevier Ltd 21.09.2023
• Subjects: Antioxidants - metabolism; cancer; Cell Death; coenzyme Q10; endoperoxide; Ferroptosis; FSP1; glutathione; GPX4; Humans; Lipid Peroxidation; Neoplasms - drug therapy; small molecule screen; coenzyme Q10; ferroptosis; cell death; GPX4; endoperoxide; glutathione; cancer; small molecule screen; lipid peroxidation; FSP1

Ferroptosis is a regulated form of cell death associated with the iron-dependent accumulation of phospholipid hydroperoxides. Inducing ferroptosis is a promising approach to treat therapy-resistant cancer. Ferroptosis suppressor protein 1 (FSP1) promotes ferroptosis resistance in cancer by generatin...