Hypoxia induced exosomal circRNA promotes metastasis of Colorectal Cancer via targeting GEF-H1/RhoA axis

• Published in: Theranostics Vol. 10; no. 18; pp. 8211 - 8226
• Main Authors: Yang, Haiou, Zhang, Haiyang, Yang, Yuchong, Wang, Xinyi, Deng, Ting, Liu, Rui, Ning, Tao, Bai, Ming, Li, Hongli, Zhu, Kegan, Li, Jialu, Fan, Qian, Ying, Guoguang, Ba, Yi
• Format: Journal Article
• Language: English
• Published: Australia Ivyspring International Publisher Pty Ltd 01.01.2020; Ivyspring International Publisher
• Subjects: Animal research; Animals; Blood vessels; Cell culture; Cell Hypoxia - genetics; Cell Line, Tumor; Cell Movement - genetics; Colorectal cancer; Colorectal Neoplasms - genetics; Colorectal Neoplasms - pathology; Colorectal Neoplasms - surgery; Communication; Disease Progression; Epoxy resins; Exosomes - metabolism; Female; Gene Expression Regulation, Neoplastic; Hospitals; Humans; Hypoxia; Male; Medical prognosis; Metastasis; Mice; MicroRNAs; MicroRNAs - metabolism; Middle Aged; Phosphorylation; Proteins; Research Paper; Rho Guanine Nucleotide Exchange Factors - genetics; rhoA GTP-Binding Protein - genetics; RNA, Circular - metabolism; Signal Transduction - genetics; Transmission electron microscopy; United States > US; China; circRNAs; hypoxia; colorectal cancer; exosomes; cancer metastasis

Hypoxia is one of the important properties of solid tumor. However, oxygen supply within tumors is generally heterogeneous according to the distance from the nearest blood vessel. The discrepancy of metastatic potential exists between hypoxic cancer cells and relatively normoxic cancer cells. But th...