Multiple New Paralytic Shellfish Toxin Vectors in Offshore North Sea Benthos, a Deep Secret Exposed

• Published in: Marine drugs Vol. 18; no. 8; p. 400
• Main Authors: Dean, Karl J, Hatfield, Robert G, Lee, Vanessa, Alexander, Ryan P, Lewis, Adam M, Maskrey, Benjamin H, Teixeira Alves, Mickael, Hatton, Benjamin, Coates, Lewis N, Capuzzo, Elisa, Ellis, Jim R, Turner, Andrew D
• Format: Journal Article
• Language: English
• Published: Switzerland MDPI AG 29.07.2020; MDPI
• Subjects: Animals; Aquatic crustaceans; Aquatic Organisms - chemistry; benthic organisms; Benthos; Benthos collecting devices; Chromatography; Crustacea - chemistry; Crustaceans; Cyanobacteria; Cysts; Demersal fisheries; Environmental health; Environmental Monitoring; Epidemiology; Epifauna; Gonyautoxin; Identification; Identification methods; Invertebrates; Marine invertebrates; Methods; New species; North Sea; Offshore; Organisms; paralytic shellfish toxins; Profiles; Saxitoxin; Saxitoxin - analogs & derivatives; Saxitoxin - analysis; saxitoxins; sea chervil; Sea Urchins - chemistry; Shellfish; Shellfish Poisoning; starfish; Starfish - chemistry; Storms; sunstar; Surveys; Toxicity; Toxins; Vectors; Water quality; Zoobenthos; North Sea; United Kingdom > UK; England; Scotland; benthic organisms; paralytic shellfish toxins; sea chervil; sunstar; starfish; saxitoxins
• ISSN: 1660-3397; 1660-3397
• DOI: 10.3390/MD18080400

In early 2018, a large easterly storm hit the East Anglian coast of the UK, colloquially known as the 'Beast from the East', which also resulted in mass strandings of benthic organisms. There were subsequent instances of dogs consuming such organisms, leading to illness and, in some cases, fatalities. Epidemiological investigations identified paralytic shellfish toxins (PSTs) as the cause, with toxins present in a range of species and concentrations exceeding 14,000 µg STX eq./kg in the sunstar . This study sought to better elucidate the geographic spread of any toxicity and identify any key organisms of concern. During the summers of 2018 and 2019, various species of benthic invertebrates were collected from demersal trawl surveys conducted across a variety of locations in the North Sea. An analysis of the benthic epifauna using two independent PST testing methods identified a 'hot spot' of toxic organisms in the Southern Bight, with a mean toxicity of 449 µg STX eq./kg. PSTs were quantified in sea chervil ( ), the first known detection in the phylum bryozoan, as well as eleven other new vectors (>50 µg STX eq./kg), namely the opisthobranch , the starfish , and , the brittlestar , the crustaceans and , the sea mouse , and the sea urchin . The two species that showed consistently high PST concentrations were and . Two toxic profiles were identified, with one dominated by dcSTX (decarbamoylsaxitoxin) associated with the majority of samples across the whole sampling region. The second profile occurred only in North-Eastern England and consisted of mostly STX (Saxitoxin) and GTX2 (gonyautoxin 2). Consequently, this study highlights widespread and variable levels of PSTs in the marine benthos, together with the first evidence for toxicity in a large number of new species. These findings highlight impacts to 'One Health', with the unexpected sources of toxins potentially creating risks to animal, human and environmental health, with further work required to assess the severity and geographical/temporal extent of these impacts.