Minicells: Versatile vectors for targeted drug or si/shRNA cancer therapy

• Published in: Current opinion in biotechnology Vol. 22; no. 6; pp. 909 - 916
• Main Authors: MacDiarmid, Jennifer A, Brahmbhatt, Himanshu
• Format: Journal Article
• Language: English
• Published: England Elsevier Ltd 01.12.2011
• Subjects: Animals; antibodies; Antibodies - metabolism; Antineoplastic Agents - administration & dosage; Antineoplastic Agents - therapeutic use; case studies; Cells - immunology; Cells - metabolism; Drug Delivery Systems; drug resistance; drug therapy; drugs; Humans; immune response; Internal Medicine; intravenous injection; medicine; mice; neoplasm cells; neoplasms; Neoplasms - therapy; RNA, Small Interfering - administration & dosage; RNA, Small Interfering - therapeutic use; small interfering RNA; toxicity

Highlights ► Targeted drug or siRNA delivery in cancer remains a serious hurdle. ► Minicells provide a versatile solution for targeted drug or siRNA delivery. ► Minicell-based delivery packages nanoscale levels of drugs or siRNAs. ► In vivo xenografts in mice show dramatic enhancement of therapeutic...