Minicells: Versatile vectors for targeted drug or si/shRNA cancer therapy

Highlights ► Targeted drug or siRNA delivery in cancer remains a serious hurdle. ► Minicells provide a versatile solution for targeted drug or siRNA delivery. ► Minicell-based delivery packages nanoscale levels of drugs or siRNAs. ► In vivo xenografts in mice show dramatic enhancement of therapeutic...

Full description

Saved in:
Bibliographic Details
Published inCurrent opinion in biotechnology Vol. 22; no. 6; pp. 909 - 916
Main Authors MacDiarmid, Jennifer A, Brahmbhatt, Himanshu
Format Journal Article
LanguageEnglish
Published England Elsevier Ltd 01.12.2011
Subjects
Animals
antibodies
Antibodies - metabolism
Antineoplastic Agents - administration & dosage
Antineoplastic Agents - therapeutic use
case studies
Cells - immunology
Cells - metabolism
Drug Delivery Systems
drug resistance
drug therapy
drugs
Humans
immune response
Internal Medicine
intravenous injection
medicine
mice
neoplasm cells
neoplasms
Neoplasms - therapy
RNA, Small Interfering - administration & dosage
RNA, Small Interfering - therapeutic use
small interfering RNA
toxicity
Online AccessGet full text

Cover

Abstract Highlights ► Targeted drug or siRNA delivery in cancer remains a serious hurdle. ► Minicells provide a versatile solution for targeted drug or siRNA delivery. ► Minicell-based delivery packages nanoscale levels of drugs or siRNAs. ► In vivo xenografts in mice show dramatic enhancement of therapeutic index. ► Monkey toxicology trials show repeat dosing without toxicity or immunogenicity.
AbstractList Highlights ► Targeted drug or siRNA delivery in cancer remains a serious hurdle. ► Minicells provide a versatile solution for targeted drug or siRNA delivery. ► Minicell-based delivery packages nanoscale levels of drugs or siRNAs. ► In vivo xenografts in mice show dramatic enhancement of therapeutic index. ► Monkey toxicology trials show repeat dosing without toxicity or immunogenicity.
Effective cancer therapy continues to be a daunting challenge due mainly to considerable tumor cell heterogeneity, drug-resistance, and dose-limiting toxicity of therapeutics. Here we review a versatile nano-cellular (minicell) delivery vehicle that can be packaged with therapeutically effective concentrations of chemotherapeutic drugs, siRNAs or shRNAs and can be targeted to tumors via minicell-surface attached bispecific antibodies. A range of minicell-based therapeutics have shown highly effective tumor stabilization/regression in the murine xenograft model and in case studies in canines with late-stage endogenous tumors. Repeat intravenous dosing shows absence of toxicity or immunogenicity in both species. The minicell-based therapeutic has potential applications in personalized cancer medicine.
► Targeted drug or siRNA delivery in cancer remains a serious hurdle. ► Minicells provide a versatile solution for targeted drug or siRNA delivery. ► Minicell-based delivery packages nanoscale levels of drugs or siRNAs. ► In vivo xenografts in mice show dramatic enhancement of therapeutic index. ► Monkey toxicology trials show repeat dosing without toxicity or immunogenicity. Effective cancer therapy continues to be a daunting challenge due mainly to considerable tumor cell heterogeneity, drug-resistance, and dose-limiting toxicity of therapeutics. Here we review a versatile nano-cellular (minicell) delivery vehicle that can be packaged with therapeutically effective concentrations of chemotherapeutic drugs, siRNAs or shRNAs and can be targeted to tumors via minicell-surface attached bispecific antibodies. A range of minicell-based therapeutics have shown highly effective tumor stabilization/regression in the murine xenograft model and in case studies in canines with late-stage endogenous tumors. Repeat intravenous dosing shows absence of toxicity or immunogenicity in both species. The minicell-based therapeutic has potential applications in personalized cancer medicine.
Author MacDiarmid, Jennifer A
Brahmbhatt, Himanshu
Author_xml – sequence: 1
  fullname: MacDiarmid, Jennifer A
– sequence: 2
  fullname: Brahmbhatt, Himanshu
BackLink https://www.ncbi.nlm.nih.gov/pubmed/21550793$$D View this record in MEDLINE/PubMed
BookMark eNqFkkFP3DAQha2KqizQf1C1ufWU4HGcOO6hEkKFItFWKtCr5diTxdtsvNgJ0v77OgrlwIWTJfubN-P35ogcDH5AQj4ALYBCfbopjN-1zheMAhSUF5Q2b8gKGiFzypk8ICsqqyaHupaH5CjGDaW0KgV9Rw4ZVBUVslyRqx9ucAb7Pn7J_mCIenQ9Zo9oRh9i1vmQjTqscUSb2TCts3QR3Wm8__3zLDN6MJiAewx6tz8hbzvdR3z_dB6Tu4tvt-ff8-tfl1fnZ9e54YKNOWMNcq6lrZEL6CoKRgprtGy7rhScWSirdn7kprS87EzdCCFby2uUumZteUw-L7q74B8mjKPaujj_QA_op6gkMAlSSPY6SZvUsGFlIvlCmuBjDNipXXBbHfYKqJrdVhu1uK1mtxXlKrmdyj4-NZjaLdrnov_2JuDTAnTaK70OLqq7m6RQpyiACSYS8XUhMFn26DCoaBwmX60LKQRlvXtthpcCpp8j1f1f3GPc-CkMKQ4FKjJF1c28E_NKAKQZBED5DxjUsUc
CitedBy_id crossref_primary_10_1016_j_jconrel_2012_05_051
crossref_primary_10_1039_D2CS00142J
crossref_primary_10_1016_j_biotechadv_2017_03_002
crossref_primary_10_1016_j_matt_2020_09_020
crossref_primary_10_1016_j_jocn_2015_06_005
crossref_primary_10_1016_j_biotechadv_2019_04_012
crossref_primary_10_1016_S1470_2045_17_30621_6
crossref_primary_10_1371_journal_pone_0144559
crossref_primary_10_1093_cvr_cvaa071
crossref_primary_10_1088_1361_6528_ab12f4
crossref_primary_10_3390_cells9010137
crossref_primary_10_1016_j_molmed_2012_05_006
crossref_primary_10_1039_c2nr32867d
crossref_primary_10_1021_acssynbio_1c00012
crossref_primary_10_1161_CIRCRESAHA_120_315855
crossref_primary_10_3390_pharmaceutics14020397
crossref_primary_10_1002_jctb_4555
crossref_primary_10_1007_s00253_013_4926_6
crossref_primary_10_1016_j_omtn_2019_12_004
crossref_primary_10_1208_s12249_018_1183_0
crossref_primary_10_1016_j_addr_2013_08_006
crossref_primary_10_1002_jgm_3097
crossref_primary_10_1016_j_copbio_2015_07_005
crossref_primary_10_1007_s43032_024_01520_z
crossref_primary_10_1016_j_canlet_2018_09_011
crossref_primary_10_4161_19420862_2014_985952
crossref_primary_10_1002_bit_27596
crossref_primary_10_1186_s12943_021_01346_2
crossref_primary_10_3390_cells12111464
crossref_primary_10_1016_j_canlet_2020_07_024
crossref_primary_10_1186_s12951_016_0172_2
crossref_primary_10_4155_tde_14_113
crossref_primary_10_1007_s40820_021_00630_6
crossref_primary_10_1155_2017_6847297
crossref_primary_10_3390_ma14133611
crossref_primary_10_1186_s13619_021_00077_5
crossref_primary_10_1016_j_addr_2022_114444
crossref_primary_10_1186_s12935_024_03420_3
crossref_primary_10_3390_pharmaceutics13081193
crossref_primary_10_1111_ans_15032
crossref_primary_10_2217_nnm_13_179
crossref_primary_10_1016_j_addr_2013_08_012
crossref_primary_10_1186_s10020_021_00293_4
crossref_primary_10_18632_oncotarget_20409
crossref_primary_10_1089_hum_2020_199
crossref_primary_10_2147_IJN_S438164
crossref_primary_10_1128_mbio_02143_23
crossref_primary_10_1021_acsnano_2c07607
crossref_primary_10_1002_adfm_202009860
crossref_primary_10_1007_s40495_016_0073_y
crossref_primary_10_1586_17476348_2015_1081066
crossref_primary_10_1177_15330338221080974
crossref_primary_10_1016_j_drudis_2015_06_013
crossref_primary_10_1016_j_addr_2023_114696
crossref_primary_10_4155_fmc_15_107
crossref_primary_10_1016_j_prp_2023_154947
crossref_primary_10_2174_0115733947250534230922051549
Cites_doi 10.1023/B:BREA.0000010702.10130.29
10.1073/pnas.57.2.321
10.1126/science.3798106
10.1016/0092-8674(89)90586-2
10.1186/bcr432
10.1016/0955-0674(93)90143-E
10.1529/biophysj.105.075192
10.1074/jbc.M512365200
10.2174/156800909788166493
10.1038/427695a
10.1093/jjco/hyp074
10.1016/S0002-9440(10)65006-7
10.1016/j.ccr.2007.03.012
10.1038/nrc1566
10.1016/j.addr.2008.08.005
10.1126/science.1104819
10.1186/1741-7015-8-83
10.1038/35048096
10.1038/nrmicro1994
10.1111/j.1365-2958.2004.04265.x
10.1126/science.1097524
10.1016/j.addr.2009.05.006
10.1007/s12033-010-9321-2
10.1111/j.1742-4658.2010.07904.x
10.1038/nrd1632
10.1158/0008-5472.CAN-07-5810
10.1038/nrd3184
10.1016/j.addr.2010.04.009
10.1038/nbt.1547
10.2133/dmpk.22.142
10.1021/bc00017a001
10.1002/bit.21668
10.1007/978-1-59745-557-2_5
10.1016/j.sbi.2005.06.003
10.1146/annurev.biochem.75.103004.142652
10.1073/pnas.152206799
10.1200/JCO.2009.24.6116
10.1007/s10555-009-9185-8
10.1158/1078-0432.CCR-06-2405
10.1089/hum.2008.131
10.1016/S0022-2836(03)00181-5
10.1016/j.addr.2007.03.005
10.1038/nri1391
10.1016/S0959-8049(01)00231-3
10.1038/sj.bjc.6601921
10.1073/pnas.95.8.4607
10.1038/35888
ContentType Journal Article
Copyright Elsevier Ltd
2011 Elsevier Ltd
Copyright © 2011 Elsevier Ltd. All rights reserved.
Copyright_xml – notice: Elsevier Ltd
– notice: 2011 Elsevier Ltd
– notice: Copyright © 2011 Elsevier Ltd. All rights reserved.
DBID FBQ
CGR
CUY
CVF
ECM
EIF
NPM
AAYXX
CITATION
7X8
7QO
8FD
FR3
P64
DOI 10.1016/j.copbio.2011.04.008
DatabaseName AGRIS
Medline
MEDLINE
MEDLINE (Ovid)
MEDLINE
MEDLINE
PubMed
CrossRef
MEDLINE - Academic
Biotechnology Research Abstracts
Technology Research Database
Engineering Research Database
Biotechnology and BioEngineering Abstracts
DatabaseTitle MEDLINE
Medline Complete
MEDLINE with Full Text
PubMed
MEDLINE (Ovid)
CrossRef
MEDLINE - Academic
Engineering Research Database
Biotechnology Research Abstracts
Technology Research Database
Biotechnology and BioEngineering Abstracts
DatabaseTitleList
Engineering Research Database
MEDLINE - Academic

MEDLINE
Database_xml – sequence: 1
  dbid: NPM
  name: PubMed
  url: https://proxy.k.utb.cz/login?url=http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?db=PubMed
  sourceTypes: Index Database
– sequence: 2
  dbid: EIF
  name: MEDLINE
  url: https://proxy.k.utb.cz/login?url=https://www.webofscience.com/wos/medline/basic-search
  sourceTypes: Index Database
– sequence: 3
  dbid: FBQ
  name: AGRIS
  url: http://www.fao.org/agris/Centre.asp?Menu_1ID=DB&Menu_2ID=DB1&Language=EN&Content=http://www.fao.org/agris/search?Language=EN
  sourceTypes: Publisher
DeliveryMethod fulltext_linktorsrc
Discipline Engineering
Medicine
EISSN 1879-0429
EndPage 916
ExternalDocumentID 10_1016_j_copbio_2011_04_008
21550793
US201600012727
S0958166911000711
1_s2_0_S0958166911000711
Genre Journal Article
Review
GroupedDBID ---
--K
--M
-~X
.1-
.FO
.GJ
.~1
0R~
1B1
1P~
1RT
1~.
1~5
29F
4.4
457
4G.
53G
5GY
5VS
7-5
71M
8P~
9JM
9JN
AAAJQ
AABNK
AACTN
AAEDT
AAEDW
AAHBH
AAIKJ
AAKOC
AALRI
AAOAW
AAQFI
AAQXK
AARKO
AAXKI
AAXUO
ABEFU
ABFRF
ABGSF
ABJNI
ABMAC
ABNUV
ABOCM
ABUDA
ABXDB
ACDAQ
ACGFO
ACGFS
ACRLP
ADBBV
ADEWK
ADEZE
ADMUD
ADUVX
AEBSH
AEFWE
AEHWI
AEKER
AENEX
AEVXI
AFCTW
AFJKZ
AFKWA
AFRHN
AFTJW
AFXIZ
AGEKW
AGHFR
AGRDE
AGUBO
AGYEJ
AHHHB
AHPOS
AI.
AIEXJ
AIKHN
AITUG
AJOXV
AJUYK
AKRWK
AKURH
ALMA_UNASSIGNED_HOLDINGS
AMFUW
AMRAJ
ASPBG
AVWKF
AXJTR
AZFZN
BKOJK
BLXMC
CAG
CJTIS
COF
CS3
DU5
EBS
EFJIC
EJD
ENUVR
EO8
EO9
EP2
EP3
F5P
FDB
FEDTE
FGOYB
FIRID
FNPLU
FYGXN
G-2
G-Q
GBLVA
HLW
HVGLF
HZ~
IHE
J1W
KOM
LUGTX
LX3
M41
MO0
N9A
O-L
O9-
O9.
OAUVE
OK~
OZT
P-8
P-9
P2P
PC.
Q38
R2-
RIG
ROL
RPZ
SBG
SCC
SDF
SDG
SDP
SES
SEW
SPC
SPCBC
SSG
SSI
SSU
SSZ
T5K
TWZ
VH1
WUQ
Z5R
~02
~G-
AAIAV
ABYKQ
AJBFU
DOVZS
EFLBG
XFK
ABPIF
ABPTK
FBQ
CGR
CUY
CVF
ECM
EIF
NPM
AAYXX
ACRPL
ADNMO
CITATION
7X8
7QO
8FD
FR3
P64
ID FETCH-LOGICAL-c472t-228e44a9d6e471f501c97dca9bff3742d135bd6e44c3d43fc68779bd46e9a62b3
IEDL.DBID .~1
ISSN 0958-1669
IngestDate Wed Dec 04 14:28:14 EST 2024
Sat Oct 05 04:27:20 EDT 2024
Fri Dec 06 02:36:21 EST 2024
Sat Sep 28 08:00:47 EDT 2024
Wed Dec 27 19:15:37 EST 2023
Fri Feb 23 02:22:52 EST 2024
Tue Oct 15 23:02:21 EDT 2024
IsPeerReviewed true
IsScholarly true
Issue 6
Language English
License Copyright © 2011 Elsevier Ltd. All rights reserved.
https://www.elsevier.com/tdm/userlicense/1.0
LinkModel DirectLink
MergedId FETCHMERGED-LOGICAL-c472t-228e44a9d6e471f501c97dca9bff3742d135bd6e44c3d43fc68779bd46e9a62b3
Notes http://dx.doi.org/10.1016/j.copbio.2011.04.008
ObjectType-Article-2
SourceType-Scholarly Journals-1
ObjectType-Feature-3
content type line 23
ObjectType-Review-1
ObjectType-Article-1
ObjectType-Feature-2
PMID 21550793
PQID 908742823
PQPubID 23479
PageCount 8
ParticipantIDs proquest_miscellaneous_912919792
proquest_miscellaneous_908742823
crossref_primary_10_1016_j_copbio_2011_04_008
pubmed_primary_21550793
fao_agris_US201600012727
elsevier_sciencedirect_doi_10_1016_j_copbio_2011_04_008
elsevier_clinicalkeyesjournals_1_s2_0_S0958166911000711
PublicationCentury 2000
PublicationDate 2011-12-01
PublicationDateYYYYMMDD 2011-12-01
PublicationDate_xml – month: 12
  year: 2011
  text: 2011-12-01
  day: 01
PublicationDecade 2010
PublicationPlace England
PublicationPlace_xml – name: England
PublicationTitle Current opinion in biotechnology
PublicationTitleAlternate Curr Opin Biotechnol
PublicationYear 2011
Publisher Elsevier Ltd
Publisher_xml – name: Elsevier Ltd
References Fang, Nakamura, Maeda (bib0190) 2011; 63
Nestorovich, Danelon, Winterhalter, Bezrukov (bib0130) 2002; 99
Nicholson, Gee, Harper (bib0035) 2001; 37
Hong, Patel, Tamm, van den Berg (bib0155) 2006; 281
Hobbs, Monsky, Yuan, Roberts, Griffith, Torchilin, Jain (bib0195) 1998; 95
Lutkenhaus (bib0110) 2007; 76
Sorensen, Leirdal, Sioud (bib0090) 2003; 327
Pirollo, Chang (bib0085) 2008; 68
Danquah, Zhang, Mahato (bib0220) 2010
Matsumura, Maeda (bib0175) 1986; 46
MacDiarmid, Amaro-Mugridge, Madrid-Weiss, Sedilarou, Wetzel, Kochar, Brahmbhatt, Phillips, Pattison, Petti (bib0120) 2009; 27
Torchilin (bib0005) 2005; 4
Ma, King, Rothfield (bib0265) 2004; 54
Schulz (bib0140) 1993; 5
Nigg (bib0245) 2001; 2
Hashizume, Baluk, Morikawa, McLean, Thurston, Roberge, Jain, McDonald (bib0205) 2000; 156
Byrne, Betancourt, Brannon-Peppas (bib0020) 2008; 60
Maeda, Matsumura (bib0180) 1989; 6
Nagamitsu, Greish, Maeda (bib0225) 2009; 39
Jain (bib0030) 2010; 8
Shim, Kwon (bib0070) 2010; 277
Chang (bib0045) 2007; 13
Kawakami, Hashida (bib0065) 2007; 22
Aagaard, Rossi (bib0060) 2007; 59
Strebhardt (bib0235) 2010; 9
Robbins, Judge, Ambegia, Choi, Yaworski, Palmer, McClintock, MacLachlan (bib0260) 2008; 19
El-Rayes, LoRusso (bib0165) 2004; 91
Baguley (bib0250) 2010; 46
Huszar, Theoclitou, Skolnik, Herbst (bib0240) 2009; 28
Maeda, Seymour, Miyamoto (bib0185) 1992; 3
Adler, Fisher, Cohen, Hardigree (bib0095) 1967; 57
Bartlett, Davis (bib0075) 2008; 99
MacDiarmid, Mugridge, Weiss, Phillips, Burn, Paulin, Haasdyk, Dickson, Brahmbhatt, Pattison (bib0115) 2007; 11
Jain (bib0215) 2005; 307
Slamon, Clark, Wong, Levin, Ullrich, McGuire (bib0170) 1987; 235
Goda, Bacsó, Szabó (bib0230) 2009; 9
Park (bib0160) 2002; 4
Bardelli, Siena (bib0050) 2010; 28
Siwak, Tari, Lopez-Berestein (bib0200) 2002; 8
Rae, Lippman (bib0040) 2004; 83
Van den Berg (bib0150) 2005; 15
Matsumura (bib0010) 2010
Ferrari (bib0015) 2005; 5
Cerchia, Giangrande, McNamara, de Franciscis (bib0080) 2009; 535
Padera, Stoll, Tooredman, Capen, di Tomaso, Jain (bib0210) 2004; 427
Danelon, Nestrovich, Winterhalter, Ceccarelli, Bezrukov (bib0135) 2006; 90
Pagès, James, Winterhalter (bib0125) 2008; 6
Shizuo, Takeda (bib0255) 2004; 4
Greco, Vicent (bib0025) 2009; 61
De Boer, Crossley, Rothfield (bib0100) 1989; 56
Van den Berg, Black, Clemons, Rapoport (bib0145) 2004; 304
Fire, Xu, Montgomery, Kostas, Driver, Mello (bib0055) 1998; 391
Maeda (10.1016/j.copbio.2011.04.008_bib0180) 1989; 6
Aagaard (10.1016/j.copbio.2011.04.008_bib0060_1) 2007; 59
Ma (10.1016/j.copbio.2011.04.008_bib0265_1) 2004; 54
Kawakami (10.1016/j.copbio.2011.04.008_bib0065) 2007; 22
Greco (10.1016/j.copbio.2011.04.008_bib0025) 2009; 61
Bardelli (10.1016/j.copbio.2011.04.008_bib0050_1) 2010; 28
De Boer (10.1016/j.copbio.2011.04.008_bib0100) 1989; 56
Lutkenhaus (10.1016/j.copbio.2011.04.008_bib0110_1) 2007; 76
Hong (10.1016/j.copbio.2011.04.008_bib0155) 2006; 281
Nicholson (10.1016/j.copbio.2011.04.008_bib0035) 2001; 37
Goda (10.1016/j.copbio.2011.04.008_bib0230) 2009; 9
El-Rayes (10.1016/j.copbio.2011.04.008_bib0165) 2004; 91
Maeda (10.1016/j.copbio.2011.04.008_bib0185) 1992; 3
Van den Berg (10.1016/j.copbio.2011.04.008_bib0145) 2004; 304
Van den Berg (10.1016/j.copbio.2011.04.008_bib0150_1) 2005; 15
Adler (10.1016/j.copbio.2011.04.008_bib0095_1) 1967; 57
Nagamitsu (10.1016/j.copbio.2011.04.008_bib0225_1) 2009; 39
Park (10.1016/j.copbio.2011.04.008_bib0160_1) 2002; 4
Robbins (10.1016/j.copbio.2011.04.008_bib0260_1) 2008; 19
Nestorovich (10.1016/j.copbio.2011.04.008_bib0130_1) 2002; 99
Danquah (10.1016/j.copbio.2011.04.008_bib0220_1) 2010
Bartlett (10.1016/j.copbio.2011.04.008_bib0075) 2008; 99
Cerchia (10.1016/j.copbio.2011.04.008_bib0080_1) 2009; 535
Hobbs (10.1016/j.copbio.2011.04.008_bib0195_1) 1998; 95
Jain (10.1016/j.copbio.2011.04.008_bib0215_1) 2005; 307
Jain (10.1016/j.copbio.2011.04.008_bib0030_1) 2010; 8
Schulz (10.1016/j.copbio.2011.04.008_bib0140_1) 1993; 5
Nigg (10.1016/j.copbio.2011.04.008_bib0245) 2001; 2
Torchilin (10.1016/j.copbio.2011.04.008_bib0005_1) 2005; 4
Matsumura (10.1016/j.copbio.2011.04.008_bib0010) 2010
Sorensen (10.1016/j.copbio.2011.04.008_bib0090) 2003; 327
Shizuo (10.1016/j.copbio.2011.04.008_bib0255) 2004; 4
Siwak (10.1016/j.copbio.2011.04.008_bib0200) 2002; 8
Pirollo (10.1016/j.copbio.2011.04.008_bib0085_1) 2008; 68
Hashizume (10.1016/j.copbio.2011.04.008_bib0205_1) 2000; 156
Byrne (10.1016/j.copbio.2011.04.008_bib0020_1) 2008; 60
Fire (10.1016/j.copbio.2011.04.008_bib0055_1) 1998; 391
MacDiarmid (10.1016/j.copbio.2011.04.008_bib0115_1) 2007; 11
Huszar (10.1016/j.copbio.2011.04.008_bib0240) 2009; 28
Shim (10.1016/j.copbio.2011.04.008_bib0070) 2010; 277
Slamon (10.1016/j.copbio.2011.04.008_bib0170_1) 1987; 235
Chang (10.1016/j.copbio.2011.04.008_bib0045_1) 2007; 13
Baguley (10.1016/j.copbio.2011.04.008_bib0250) 2010; 46
Rae (10.1016/j.copbio.2011.04.008_bib0040) 2004; 83
Pagès (10.1016/j.copbio.2011.04.008_bib0125) 2008; 6
Fang (10.1016/j.copbio.2011.04.008_bib0190_1) 2011; 63
Ferrari (10.1016/j.copbio.2011.04.008_bib0015) 2005; 5
Matsumura (10.1016/j.copbio.2011.04.008_bib0175_1) 1986; 46
MacDiarmid (10.1016/j.copbio.2011.04.008_bib0120_1) 2009; 27
Strebhardt (10.1016/j.copbio.2011.04.008_bib0235_1) 2010; 9
Padera (10.1016/j.copbio.2011.04.008_bib0210_1) 2004; 427
Danelon (10.1016/j.copbio.2011.04.008_bib0135) 2006; 90
References_xml – volume: 91
  start-page: 418
  year: 2004
  end-page: 424
  ident: bib0165
  article-title: Targeting the epidermal growth factor receptor
  publication-title: Br J Cancer
  contributor:
    fullname: LoRusso
– volume: 60
  start-page: 1615
  year: 2008
  end-page: 1626
  ident: bib0020
  article-title: Active targeting schemes for nanoparticle systems in cancer therapeutics
  publication-title: Adv Drug Deliv Rev
  contributor:
    fullname: Brannon-Peppas
– volume: 90
  start-page: 1617
  year: 2006
  end-page: 1627
  ident: bib0135
  article-title: Interaction of zwitterionic penicillins with the OmpF channel facilitates their translocation
  publication-title: Biophys J
  contributor:
    fullname: Bezrukov
– volume: 99
  start-page: 9789
  year: 2002
  end-page: 9794
  ident: bib0130
  article-title: Designed to penetrate: time-resolved interaction of single antibiotic molecules with bacterial pores
  publication-title: Proc Natl Acad Sci USA
  contributor:
    fullname: Bezrukov
– volume: 37
  start-page: S9
  year: 2001
  end-page: S15
  ident: bib0035
  article-title: EGFR and cancer prognosis
  publication-title: Eur J Cancer
  contributor:
    fullname: Harper
– volume: 8
  start-page: 83
  year: 2010
  end-page: 94
  ident: bib0030
  article-title: Advances in the field of nanooncology
  publication-title: BMC Med
  contributor:
    fullname: Jain
– volume: 156
  start-page: 1363
  year: 2000
  end-page: 1380
  ident: bib0205
  article-title: Openings between defective endothelial cells explain tumor vessel leakiness
  publication-title: Am J Pathol
  contributor:
    fullname: McDonald
– volume: 46
  start-page: 6387
  year: 1986
  end-page: 6392
  ident: bib0175
  article-title: A new concept for macromolecular therapeutics in cancer chemotherapy: mechanism of tumoritropic accumulation of proteins and the antitumor agent smancs
  publication-title: Cancer Res
  contributor:
    fullname: Maeda
– volume: 63
  start-page: 136
  year: 2011
  end-page: 151
  ident: bib0190
  article-title: The EPR effect: unique features of tumor blood vessels for drug delivery, factors involved, and limitations and augmentation of the effect
  publication-title: Adv Drug Del Rev
  contributor:
    fullname: Maeda
– volume: 4
  start-page: 499
  year: 2004
  end-page: 511
  ident: bib0255
  article-title: Toll-like receptor signaling
  publication-title: Nature Rev Immunol
  contributor:
    fullname: Takeda
– volume: 99
  start-page: 975
  year: 2008
  end-page: 985
  ident: bib0075
  article-title: Impact of tumor-specific targeting and dosing schedule on tumor growth inhibition after intravenous administration of siRNA-containing nanoparticles
  publication-title: Biotechnol Bioeng
  contributor:
    fullname: Davis
– volume: 304
  start-page: 1506
  year: 2004
  end-page: 1509
  ident: bib0145
  article-title: Crystal structure of the long-chain fatty acid transporter FadL
  publication-title: Science
  contributor:
    fullname: Rapoport
– volume: 327
  start-page: 761
  year: 2003
  end-page: 766
  ident: bib0090
  article-title: Gene silencing by systemic delivery of synthetic siRNAs in adult mice
  publication-title: J Mol Biol
  contributor:
    fullname: Sioud
– year: 2010
  ident: bib0010
  article-title: Preclinical and clinical studies of NK012, an SN-38-incorporating polymeric micelles, which is designed based on EPR effect
  publication-title: Adv Drug Deliv Rev
  contributor:
    fullname: Matsumura
– volume: 95
  start-page: 4607
  year: 1998
  end-page: 4612
  ident: bib0195
  article-title: Regulation of transport pathways in tumor vessels: role of tumor type and microenvironment
  publication-title: Proc Natl Acad Sci USA
  contributor:
    fullname: Jain
– volume: 427
  start-page: 695
  year: 2004
  ident: bib0210
  article-title: Pathology: cancer cells compress intratumour vessels
  publication-title: Nature
  contributor:
    fullname: Jain
– volume: 2
  start-page: 21
  year: 2001
  end-page: 32
  ident: bib0245
  article-title: Mitotic kinases as regulators of cell division and its checkpoints
  publication-title: Nat Rev Mol Cell Biol
  contributor:
    fullname: Nigg
– volume: 5
  start-page: 701
  year: 1993
  end-page: 707
  ident: bib0140
  article-title: Bacterial porins: structure and function
  publication-title: Curr Opin Cell Biol
  contributor:
    fullname: Schulz
– volume: 3
  start-page: 351
  year: 1992
  end-page: 362
  ident: bib0185
  article-title: Conjugates of anticancer agents and polymers: advantages of macromolecular therapeutics in vivo
  publication-title: Bioconjug Chem
  contributor:
    fullname: Miyamoto
– volume: 46
  start-page: 308
  year: 2010
  end-page: 316
  ident: bib0250
  article-title: Multiple drug resistance mechanisms in cancer
  publication-title: Mol Biotechnol
  contributor:
    fullname: Baguley
– volume: 4
  start-page: 145
  year: 2005
  end-page: 160
  ident: bib0005
  article-title: Recent advances with liposomes as pharmaceutical carriers
  publication-title: Nat Rev Drug Discov
  contributor:
    fullname: Torchilin
– volume: 391
  start-page: 806
  year: 1998
  end-page: 811
  ident: bib0055
  article-title: Potent and specific genetic interference by double-stranded RNA in
  publication-title: Nature
  contributor:
    fullname: Mello
– volume: 76
  start-page: 539
  year: 2007
  end-page: 562
  ident: bib0110
  article-title: Assembly dynamics of the bacterial MinCDE system and spatial regulation of the Z ring
  publication-title: Ann Rev Biochem
  contributor:
    fullname: Lutkenhaus
– volume: 19
  start-page: 991
  year: 2008
  end-page: 999
  ident: bib0260
  article-title: Misinterpreting the therapeutic effects of small interfering RNA caused by immune stimulation
  publication-title: Hum Gene Ther
  contributor:
    fullname: MacLachlan
– volume: 39
  start-page: 756
  year: 2009
  end-page: 766
  ident: bib0225
  article-title: Elevating blood pressure as a strategy to increase tumor-targeted delivery of macromolecular drug SMANCS: cases of advanced solid tumors
  publication-title: Jpn J Oncol
  contributor:
    fullname: Maeda
– year: 2010
  ident: bib0220
  article-title: Extravasation of polymeric nanomedicines across tumor vasculature
  publication-title: Adv Drug Deliv Rev
  contributor:
    fullname: Mahato
– volume: 277
  start-page: 4814
  year: 2010
  end-page: 4827
  ident: bib0070
  article-title: Efficient and targeted delivery of siRNA in vivo
  publication-title: FEBS J
  contributor:
    fullname: Kwon
– volume: 8
  start-page: 955
  year: 2002
  end-page: 956
  ident: bib0200
  article-title: The potential of drug-carrying immunoliposomes as anticancer agents
  publication-title: Clin Cancer Res
  contributor:
    fullname: Lopez-Berestein
– volume: 4
  start-page: 95
  year: 2002
  end-page: 99
  ident: bib0160
  article-title: Liposome-based drug delivery in breast cancer treatment
  publication-title: Breast Cancer Res
  contributor:
    fullname: Park
– volume: 56
  start-page: 641
  year: 1989
  end-page: 649
  ident: bib0100
  article-title: A division inhibitor and a topological specificity factor coded for by the minicell locus determine proper placement of the division septum in
  publication-title: Cell
  contributor:
    fullname: Rothfield
– volume: 9
  start-page: 281
  year: 2009
  end-page: 297
  ident: bib0230
  article-title: Multidrug resistance through the spectacle of P-glycoprotein
  publication-title: Curr Cancer Drug Targets
  contributor:
    fullname: Szabó
– volume: 15
  start-page: 401
  year: 2005
  end-page: 407
  ident: bib0150
  article-title: The FadL family: unusual transporters for unusual substrates
  publication-title: Curr Opin Struct Biol
  contributor:
    fullname: Van den Berg
– volume: 68
  start-page: 1247
  year: 2008
  end-page: 1250
  ident: bib0085
  article-title: Targeted delivery of small interfering RNA: approaching effective cancer therapies
  publication-title: Cancer Res
  contributor:
    fullname: Chang
– volume: 27
  start-page: 643
  year: 2009
  end-page: 651
  ident: bib0120
  article-title: Sequential treatment of drug-resistant tumors with targeted minicells containing siRNA or a cytotoxic drug
  publication-title: Nat Biotechnol
  contributor:
    fullname: Petti
– volume: 61
  start-page: 1203
  year: 2009
  end-page: 1213
  ident: bib0025
  article-title: Combination therapy: opportunities and challenges for polymer–drug conjugates as anticancer nanomedicines
  publication-title: Adv Drug Deliv Rev
  contributor:
    fullname: Vicent
– volume: 22
  start-page: 142
  year: 2007
  end-page: 151
  ident: bib0065
  article-title: Targeted delivery systems of small interfering RNA by systemic administration
  publication-title: Drug Metab Pharmacokinet
  contributor:
    fullname: Hashida
– volume: 235
  start-page: 177
  year: 1987
  end-page: 182
  ident: bib0170
  article-title: Human breast cancer: correlation of relapse and survival with amplification of the HER-2/
  publication-title: Science
  contributor:
    fullname: McGuire
– volume: 57
  start-page: 321
  year: 1967
  end-page: 326
  ident: bib0095
  article-title: Miniature
  publication-title: Proc Natl Acad Sci USA
  contributor:
    fullname: Hardigree
– volume: 59
  start-page: 75
  year: 2007
  end-page: 86
  ident: bib0060
  article-title: RNAi therapeutics: principles, prospects and challenges
  publication-title: Adv Drug Del Rev
  contributor:
    fullname: Rossi
– volume: 5
  start-page: 161
  year: 2005
  end-page: 171
  ident: bib0015
  article-title: Cancer nanotechnology: opportunities and challenges
  publication-title: Nat Rev Cancer
  contributor:
    fullname: Ferrari
– volume: 54
  start-page: 99
  year: 2004
  end-page: 108
  ident: bib0265
  article-title: Positioning of the MinE binding site on the MinD surface suggests a plausible mechanism for activation of the
  publication-title: Mol Microbiol
  contributor:
    fullname: Rothfield
– volume: 9
  start-page: 643
  year: 2010
  end-page: 660
  ident: bib0235
  article-title: Multifaceted polo-like kinases: drug targets and antitargets for cancer therapy
  publication-title: Nat Rev Drug Discov
  contributor:
    fullname: Strebhardt
– volume: 6
  start-page: 893
  year: 2008
  end-page: 903
  ident: bib0125
  article-title: The porin and the permeating antibiotic: a selective diffusion barrier in Gram-negative bacteria
  publication-title: Nat Rev Microbiol
  contributor:
    fullname: Winterhalter
– volume: 281
  start-page: 7568
  year: 2006
  end-page: 7577
  ident: bib0155
  article-title: The outer membrane protein OmpW forms an eight-stranded beta-barrel with a hydrophobic channel
  publication-title: J Biol Chem
  contributor:
    fullname: van den Berg
– volume: 6
  start-page: 193
  year: 1989
  end-page: 210
  ident: bib0180
  article-title: Tumoritropic and lymphotropic principles of macromolecular drugs
  publication-title: Crit Rev Ther Drug Carrier Syst
  contributor:
    fullname: Matsumura
– volume: 28
  start-page: 197
  year: 2009
  end-page: 208
  ident: bib0240
  article-title: Kinesin motor proteins as targets for cancer therapy
  publication-title: Cancer Metastasis Rev
  contributor:
    fullname: Herbst
– volume: 13
  start-page: 1
  year: 2007
  end-page: 3
  ident: bib0045
  article-title: HER2 inhibition: from discovery to clinical practice
  publication-title: Clin Cancer Res
  contributor:
    fullname: Chang
– volume: 535
  start-page: 59
  year: 2009
  end-page: 78
  ident: bib0080
  article-title: Cell-specific aptamers for targeted therapies
  publication-title: Methods Mol Biol
  contributor:
    fullname: de Franciscis
– volume: 11
  start-page: 431
  year: 2007
  end-page: 445
  ident: bib0115
  article-title: Bacterially derived 400
  publication-title: Cancer Cell
  contributor:
    fullname: Pattison
– volume: 28
  start-page: 1254
  year: 2010
  end-page: 1261
  ident: bib0050
  article-title: Molecular mechanisms of resistance to cetuximab and panitumumab in colorectal cancer
  publication-title: J Clin Oncol
  contributor:
    fullname: Siena
– volume: 83
  start-page: 99
  year: 2004
  end-page: 107
  ident: bib0040
  article-title: Evaluation of novel epidermal growth factor receptor tyrosine kinase inhibitors
  publication-title: Breast Cancer Res Treat
  contributor:
    fullname: Lippman
– volume: 307
  start-page: 58
  year: 2005
  end-page: 62
  ident: bib0215
  article-title: Normalization of tumor vasculature: an emerging concept in antiangiogenic therapy
  publication-title: Science
  contributor:
    fullname: Jain
– volume: 83
  start-page: 99
  year: 2004
  ident: 10.1016/j.copbio.2011.04.008_bib0040
  article-title: Evaluation of novel epidermal growth factor receptor tyrosine kinase inhibitors
  publication-title: Breast Cancer Res Treat
  doi: 10.1023/B:BREA.0000010702.10130.29
  contributor:
    fullname: Rae
– volume: 57
  start-page: 321
  year: 1967
  ident: 10.1016/j.copbio.2011.04.008_bib0095_1
  article-title: Miniature Escherichia coli cells deficient in DNA
  publication-title: Proc Natl Acad Sci USA
  doi: 10.1073/pnas.57.2.321
  contributor:
    fullname: Adler
– volume: 235
  start-page: 177
  year: 1987
  ident: 10.1016/j.copbio.2011.04.008_bib0170_1
  article-title: Human breast cancer: correlation of relapse and survival with amplification of the HER-2/neu oncogene
  publication-title: Science
  doi: 10.1126/science.3798106
  contributor:
    fullname: Slamon
– volume: 56
  start-page: 641
  year: 1989
  ident: 10.1016/j.copbio.2011.04.008_bib0100
  article-title: A division inhibitor and a topological specificity factor coded for by the minicell locus determine proper placement of the division septum in E. coli
  publication-title: Cell
  doi: 10.1016/0092-8674(89)90586-2
  contributor:
    fullname: De Boer
– volume: 4
  start-page: 95
  year: 2002
  ident: 10.1016/j.copbio.2011.04.008_bib0160_1
  article-title: Liposome-based drug delivery in breast cancer treatment
  publication-title: Breast Cancer Res
  doi: 10.1186/bcr432
  contributor:
    fullname: Park
– volume: 5
  start-page: 701
  year: 1993
  ident: 10.1016/j.copbio.2011.04.008_bib0140_1
  article-title: Bacterial porins: structure and function
  publication-title: Curr Opin Cell Biol
  doi: 10.1016/0955-0674(93)90143-E
  contributor:
    fullname: Schulz
– volume: 90
  start-page: 1617
  year: 2006
  ident: 10.1016/j.copbio.2011.04.008_bib0135
  article-title: Interaction of zwitterionic penicillins with the OmpF channel facilitates their translocation
  publication-title: Biophys J
  doi: 10.1529/biophysj.105.075192
  contributor:
    fullname: Danelon
– volume: 281
  start-page: 7568
  year: 2006
  ident: 10.1016/j.copbio.2011.04.008_bib0155
  article-title: The outer membrane protein OmpW forms an eight-stranded beta-barrel with a hydrophobic channel
  publication-title: J Biol Chem
  doi: 10.1074/jbc.M512365200
  contributor:
    fullname: Hong
– volume: 9
  start-page: 281
  year: 2009
  ident: 10.1016/j.copbio.2011.04.008_bib0230
  article-title: Multidrug resistance through the spectacle of P-glycoprotein
  publication-title: Curr Cancer Drug Targets
  doi: 10.2174/156800909788166493
  contributor:
    fullname: Goda
– volume: 427
  start-page: 695
  year: 2004
  ident: 10.1016/j.copbio.2011.04.008_bib0210_1
  article-title: Pathology: cancer cells compress intratumour vessels
  publication-title: Nature
  doi: 10.1038/427695a
  contributor:
    fullname: Padera
– volume: 39
  start-page: 756
  year: 2009
  ident: 10.1016/j.copbio.2011.04.008_bib0225_1
  article-title: Elevating blood pressure as a strategy to increase tumor-targeted delivery of macromolecular drug SMANCS: cases of advanced solid tumors
  publication-title: Jpn J Oncol
  doi: 10.1093/jjco/hyp074
  contributor:
    fullname: Nagamitsu
– volume: 156
  start-page: 1363
  year: 2000
  ident: 10.1016/j.copbio.2011.04.008_bib0205_1
  article-title: Openings between defective endothelial cells explain tumor vessel leakiness
  publication-title: Am J Pathol
  doi: 10.1016/S0002-9440(10)65006-7
  contributor:
    fullname: Hashizume
– volume: 11
  start-page: 431
  year: 2007
  ident: 10.1016/j.copbio.2011.04.008_bib0115_1
  article-title: Bacterially derived 400nm particles for encapsulation and cancer cell targeting of chemotherapeutics
  publication-title: Cancer Cell
  doi: 10.1016/j.ccr.2007.03.012
  contributor:
    fullname: MacDiarmid
– volume: 5
  start-page: 161
  year: 2005
  ident: 10.1016/j.copbio.2011.04.008_bib0015
  article-title: Cancer nanotechnology: opportunities and challenges
  publication-title: Nat Rev Cancer
  doi: 10.1038/nrc1566
  contributor:
    fullname: Ferrari
– volume: 60
  start-page: 1615
  year: 2008
  ident: 10.1016/j.copbio.2011.04.008_bib0020_1
  article-title: Active targeting schemes for nanoparticle systems in cancer therapeutics
  publication-title: Adv Drug Deliv Rev
  doi: 10.1016/j.addr.2008.08.005
  contributor:
    fullname: Byrne
– volume: 307
  start-page: 58
  year: 2005
  ident: 10.1016/j.copbio.2011.04.008_bib0215_1
  article-title: Normalization of tumor vasculature: an emerging concept in antiangiogenic therapy
  publication-title: Science
  doi: 10.1126/science.1104819
  contributor:
    fullname: Jain
– volume: 8
  start-page: 83
  year: 2010
  ident: 10.1016/j.copbio.2011.04.008_bib0030_1
  article-title: Advances in the field of nanooncology
  publication-title: BMC Med
  doi: 10.1186/1741-7015-8-83
  contributor:
    fullname: Jain
– volume: 2
  start-page: 21
  year: 2001
  ident: 10.1016/j.copbio.2011.04.008_bib0245
  article-title: Mitotic kinases as regulators of cell division and its checkpoints
  publication-title: Nat Rev Mol Cell Biol
  doi: 10.1038/35048096
  contributor:
    fullname: Nigg
– volume: 6
  start-page: 893
  year: 2008
  ident: 10.1016/j.copbio.2011.04.008_bib0125
  article-title: The porin and the permeating antibiotic: a selective diffusion barrier in Gram-negative bacteria
  publication-title: Nat Rev Microbiol
  doi: 10.1038/nrmicro1994
  contributor:
    fullname: Pagès
– volume: 54
  start-page: 99
  year: 2004
  ident: 10.1016/j.copbio.2011.04.008_bib0265_1
  article-title: Positioning of the MinE binding site on the MinD surface suggests a plausible mechanism for activation of the Escherichia coli MinD ATPase during division site selection
  publication-title: Mol Microbiol
  doi: 10.1111/j.1365-2958.2004.04265.x
  contributor:
    fullname: Ma
– year: 2010
  ident: 10.1016/j.copbio.2011.04.008_bib0010
  article-title: Preclinical and clinical studies of NK012, an SN-38-incorporating polymeric micelles, which is designed based on EPR effect
  publication-title: Adv Drug Deliv Rev
  contributor:
    fullname: Matsumura
– volume: 304
  start-page: 1506
  year: 2004
  ident: 10.1016/j.copbio.2011.04.008_bib0145
  article-title: Crystal structure of the long-chain fatty acid transporter FadL
  publication-title: Science
  doi: 10.1126/science.1097524
  contributor:
    fullname: Van den Berg
– volume: 61
  start-page: 1203
  year: 2009
  ident: 10.1016/j.copbio.2011.04.008_bib0025
  article-title: Combination therapy: opportunities and challenges for polymer–drug conjugates as anticancer nanomedicines
  publication-title: Adv Drug Deliv Rev
  doi: 10.1016/j.addr.2009.05.006
  contributor:
    fullname: Greco
– volume: 46
  start-page: 308
  year: 2010
  ident: 10.1016/j.copbio.2011.04.008_bib0250
  article-title: Multiple drug resistance mechanisms in cancer
  publication-title: Mol Biotechnol
  doi: 10.1007/s12033-010-9321-2
  contributor:
    fullname: Baguley
– volume: 277
  start-page: 4814
  year: 2010
  ident: 10.1016/j.copbio.2011.04.008_bib0070
  article-title: Efficient and targeted delivery of siRNA in vivo
  publication-title: FEBS J
  doi: 10.1111/j.1742-4658.2010.07904.x
  contributor:
    fullname: Shim
– volume: 6
  start-page: 193
  year: 1989
  ident: 10.1016/j.copbio.2011.04.008_bib0180
  article-title: Tumoritropic and lymphotropic principles of macromolecular drugs
  publication-title: Crit Rev Ther Drug Carrier Syst
  contributor:
    fullname: Maeda
– volume: 4
  start-page: 145
  year: 2005
  ident: 10.1016/j.copbio.2011.04.008_bib0005_1
  article-title: Recent advances with liposomes as pharmaceutical carriers
  publication-title: Nat Rev Drug Discov
  doi: 10.1038/nrd1632
  contributor:
    fullname: Torchilin
– volume: 68
  start-page: 1247
  year: 2008
  ident: 10.1016/j.copbio.2011.04.008_bib0085_1
  article-title: Targeted delivery of small interfering RNA: approaching effective cancer therapies
  publication-title: Cancer Res
  doi: 10.1158/0008-5472.CAN-07-5810
  contributor:
    fullname: Pirollo
– volume: 9
  start-page: 643
  year: 2010
  ident: 10.1016/j.copbio.2011.04.008_bib0235_1
  article-title: Multifaceted polo-like kinases: drug targets and antitargets for cancer therapy
  publication-title: Nat Rev Drug Discov
  doi: 10.1038/nrd3184
  contributor:
    fullname: Strebhardt
– volume: 63
  start-page: 136
  year: 2011
  ident: 10.1016/j.copbio.2011.04.008_bib0190_1
  article-title: The EPR effect: unique features of tumor blood vessels for drug delivery, factors involved, and limitations and augmentation of the effect
  publication-title: Adv Drug Del Rev
  doi: 10.1016/j.addr.2010.04.009
  contributor:
    fullname: Fang
– volume: 27
  start-page: 643
  year: 2009
  ident: 10.1016/j.copbio.2011.04.008_bib0120_1
  article-title: Sequential treatment of drug-resistant tumors with targeted minicells containing siRNA or a cytotoxic drug
  publication-title: Nat Biotechnol
  doi: 10.1038/nbt.1547
  contributor:
    fullname: MacDiarmid
– volume: 22
  start-page: 142
  year: 2007
  ident: 10.1016/j.copbio.2011.04.008_bib0065
  article-title: Targeted delivery systems of small interfering RNA by systemic administration
  publication-title: Drug Metab Pharmacokinet
  doi: 10.2133/dmpk.22.142
  contributor:
    fullname: Kawakami
– volume: 3
  start-page: 351
  year: 1992
  ident: 10.1016/j.copbio.2011.04.008_bib0185
  article-title: Conjugates of anticancer agents and polymers: advantages of macromolecular therapeutics in vivo
  publication-title: Bioconjug Chem
  doi: 10.1021/bc00017a001
  contributor:
    fullname: Maeda
– volume: 99
  start-page: 975
  year: 2008
  ident: 10.1016/j.copbio.2011.04.008_bib0075
  article-title: Impact of tumor-specific targeting and dosing schedule on tumor growth inhibition after intravenous administration of siRNA-containing nanoparticles
  publication-title: Biotechnol Bioeng
  doi: 10.1002/bit.21668
  contributor:
    fullname: Bartlett
– volume: 535
  start-page: 59
  year: 2009
  ident: 10.1016/j.copbio.2011.04.008_bib0080_1
  article-title: Cell-specific aptamers for targeted therapies
  publication-title: Methods Mol Biol
  doi: 10.1007/978-1-59745-557-2_5
  contributor:
    fullname: Cerchia
– volume: 15
  start-page: 401
  year: 2005
  ident: 10.1016/j.copbio.2011.04.008_bib0150_1
  article-title: The FadL family: unusual transporters for unusual substrates
  publication-title: Curr Opin Struct Biol
  doi: 10.1016/j.sbi.2005.06.003
  contributor:
    fullname: Van den Berg
– volume: 76
  start-page: 539
  year: 2007
  ident: 10.1016/j.copbio.2011.04.008_bib0110_1
  article-title: Assembly dynamics of the bacterial MinCDE system and spatial regulation of the Z ring
  publication-title: Ann Rev Biochem
  doi: 10.1146/annurev.biochem.75.103004.142652
  contributor:
    fullname: Lutkenhaus
– volume: 8
  start-page: 955
  year: 2002
  ident: 10.1016/j.copbio.2011.04.008_bib0200
  article-title: The potential of drug-carrying immunoliposomes as anticancer agents
  publication-title: Clin Cancer Res
  contributor:
    fullname: Siwak
– volume: 99
  start-page: 9789
  year: 2002
  ident: 10.1016/j.copbio.2011.04.008_bib0130_1
  article-title: Designed to penetrate: time-resolved interaction of single antibiotic molecules with bacterial pores
  publication-title: Proc Natl Acad Sci USA
  doi: 10.1073/pnas.152206799
  contributor:
    fullname: Nestorovich
– volume: 28
  start-page: 1254
  year: 2010
  ident: 10.1016/j.copbio.2011.04.008_bib0050_1
  article-title: Molecular mechanisms of resistance to cetuximab and panitumumab in colorectal cancer
  publication-title: J Clin Oncol
  doi: 10.1200/JCO.2009.24.6116
  contributor:
    fullname: Bardelli
– volume: 28
  start-page: 197
  year: 2009
  ident: 10.1016/j.copbio.2011.04.008_bib0240
  article-title: Kinesin motor proteins as targets for cancer therapy
  publication-title: Cancer Metastasis Rev
  doi: 10.1007/s10555-009-9185-8
  contributor:
    fullname: Huszar
– volume: 13
  start-page: 1
  year: 2007
  ident: 10.1016/j.copbio.2011.04.008_bib0045_1
  article-title: HER2 inhibition: from discovery to clinical practice
  publication-title: Clin Cancer Res
  doi: 10.1158/1078-0432.CCR-06-2405
  contributor:
    fullname: Chang
– year: 2010
  ident: 10.1016/j.copbio.2011.04.008_bib0220_1
  article-title: Extravasation of polymeric nanomedicines across tumor vasculature
  publication-title: Adv Drug Deliv Rev
  contributor:
    fullname: Danquah
– volume: 19
  start-page: 991
  year: 2008
  ident: 10.1016/j.copbio.2011.04.008_bib0260_1
  article-title: Misinterpreting the therapeutic effects of small interfering RNA caused by immune stimulation
  publication-title: Hum Gene Ther
  doi: 10.1089/hum.2008.131
  contributor:
    fullname: Robbins
– volume: 46
  start-page: 6387
  year: 1986
  ident: 10.1016/j.copbio.2011.04.008_bib0175_1
  article-title: A new concept for macromolecular therapeutics in cancer chemotherapy: mechanism of tumoritropic accumulation of proteins and the antitumor agent smancs
  publication-title: Cancer Res
  contributor:
    fullname: Matsumura
– volume: 327
  start-page: 761
  year: 2003
  ident: 10.1016/j.copbio.2011.04.008_bib0090
  article-title: Gene silencing by systemic delivery of synthetic siRNAs in adult mice
  publication-title: J Mol Biol
  doi: 10.1016/S0022-2836(03)00181-5
  contributor:
    fullname: Sorensen
– volume: 59
  start-page: 75
  year: 2007
  ident: 10.1016/j.copbio.2011.04.008_bib0060_1
  article-title: RNAi therapeutics: principles, prospects and challenges
  publication-title: Adv Drug Del Rev
  doi: 10.1016/j.addr.2007.03.005
  contributor:
    fullname: Aagaard
– volume: 4
  start-page: 499
  year: 2004
  ident: 10.1016/j.copbio.2011.04.008_bib0255
  article-title: Toll-like receptor signaling
  publication-title: Nature Rev Immunol
  doi: 10.1038/nri1391
  contributor:
    fullname: Shizuo
– volume: 37
  start-page: S9
  year: 2001
  ident: 10.1016/j.copbio.2011.04.008_bib0035
  article-title: EGFR and cancer prognosis
  publication-title: Eur J Cancer
  doi: 10.1016/S0959-8049(01)00231-3
  contributor:
    fullname: Nicholson
– volume: 91
  start-page: 418
  year: 2004
  ident: 10.1016/j.copbio.2011.04.008_bib0165
  article-title: Targeting the epidermal growth factor receptor
  publication-title: Br J Cancer
  doi: 10.1038/sj.bjc.6601921
  contributor:
    fullname: El-Rayes
– volume: 95
  start-page: 4607
  year: 1998
  ident: 10.1016/j.copbio.2011.04.008_bib0195_1
  article-title: Regulation of transport pathways in tumor vessels: role of tumor type and microenvironment
  publication-title: Proc Natl Acad Sci USA
  doi: 10.1073/pnas.95.8.4607
  contributor:
    fullname: Hobbs
– volume: 391
  start-page: 806
  year: 1998
  ident: 10.1016/j.copbio.2011.04.008_bib0055_1
  article-title: Potent and specific genetic interference by double-stranded RNA in Caenorhabditis elegans
  publication-title: Nature
  doi: 10.1038/35888
  contributor:
    fullname: Fire
SSID ssj0005370
Score 2.3530774
SecondaryResourceType review_article
Snippet Highlights ► Targeted drug or siRNA delivery in cancer remains a serious hurdle. ► Minicells provide a versatile solution for targeted drug or siRNA delivery....
► Targeted drug or siRNA delivery in cancer remains a serious hurdle. ► Minicells provide a versatile solution for targeted drug or siRNA delivery. ►...
Effective cancer therapy continues to be a daunting challenge due mainly to considerable tumor cell heterogeneity, drug-resistance, and dose-limiting toxicity...
SourceID proquest
crossref
pubmed
fao
elsevier
SourceType Aggregation Database
Index Database
Publisher
StartPage 909
SubjectTerms Animals
antibodies
Antibodies - metabolism
Antineoplastic Agents - administration & dosage
Antineoplastic Agents - therapeutic use
case studies
Cells - immunology
Cells - metabolism
Drug Delivery Systems
drug resistance
drug therapy
drugs
Humans
immune response
Internal Medicine
intravenous injection
medicine
mice
neoplasm cells
neoplasms
Neoplasms - therapy
RNA, Small Interfering - administration & dosage
RNA, Small Interfering - therapeutic use
small interfering RNA
toxicity
Title Minicells: Versatile vectors for targeted drug or si/shRNA cancer therapy
URI https://www.clinicalkey.es/playcontent/1-s2.0-S0958166911000711
https://dx.doi.org/10.1016/j.copbio.2011.04.008
https://www.ncbi.nlm.nih.gov/pubmed/21550793
https://search.proquest.com/docview/908742823
https://search.proquest.com/docview/912919792
Volume 22
hasFullText 1
inHoldings 1
isFullTextHit
isPrint
link http://utb.summon.serialssolutions.com/2.0.0/link/0/eLvHCXMwnV1LT9wwELYoXNpDBX2xvOQD13QT24ljbisEWlqxB-hK3CzHD7potVmR3R757cw4CdqqopV6dRwl-mY8M7ZnviHkVPICovoiJIX1JhGCV4nJYM9jVBZSEUxuHdYOX0-K8VR8u8vvtsh5XwuDaZWd7W9terTW3ciwQ3O4nM2GtxAc4KWXQtIzcJSxgj1PsYvB16eNNA8eG8bh5ARn9-VzMcfL1stqVndEnkijXb7mnt4EU78ehEZndLlL3ndRJB21P7pHtvziA3m3wS34kVxdY8mjn8-bM4qHYiCBuae_4iF9QyFUpW0SuHfUPa7vKQw0s2Hz82YyohZVASa0jAOfyPTy4sf5OOn6JiRWSLZKGCu9EEa5woPrCXmaWSWdNaoKgcNW2GU8r_ChsNwJHmxRSqkqJwqvTMEq_plsL-qF3yfUyUwZpgx2hQGJmlJJWyIDTchSlxs2IEkPl1629Bi6zxt70C28GuHVqdAA74DIHlPdl36CsfJNt3IanemG6VT_Id3NN39TEA22_x_f3AfhaXMPVlNPbxly6sUbdyYHhPYS1bCsUChm4et1o1VaAlIl43-ZAqFSpqQCEL60yvACAcONH1i-g__-6UPyNp5ex8SZI7K9elz7Ywh_VtVJ1O8TsjO6-j6ePANbzACL
link.rule.ids 314,780,784,4502,24116,27924,27925,45585,45679
linkProvider Elsevier
linkToHtml http://utb.summon.serialssolutions.com/2.0.0/link/0/eLvHCXMwnV1LT9wwELYoPbQ9IPpkKbQ-9JpuYjtx3BtCRUvL7qGwEjfL8QO2Wm1WZLdHfjszTlJthSgSV2eiRN-MZz7bM2NCvkheAKsvQlJYbxIheJWYDNY8RmUhFcHk1mHt8HhSjKbix2V-uUWO-1oYTKvsfH_r06O37kaGHZrD5Ww2PAdygIdeCpueQaCEJdBzkQP7BaP-eruR58HjjXEonaB4Xz8Xk7xsvaxmddfJE_tolw_Fp2fB1A-z0BiNTnbJTkcj6VH7p6_Jll-8Ia82mgu-JadjrHn083nzjeKuGKhg7umfuEvfUOCqtM0C9466m_UVhYFmNmyuf02OqEVbAIG25cA7Mj35fnE8SrqLExIrJFsljJVeCKNc4SH2hDzNrJLOGlWFwGEt7DKeV_hQWO4ED7YopVSVE4VXpmAVf0-2F_XC7xHqZKYMUwavhQGVmlJJW2ILmpClLjdsQJIeLr1s-2PoPnHst27h1QivToUGeAdE9pjqvvYTvJVvuqnT6Ew3TKf6nno33_zHQjQ4_0e-uQfK0-YK3KaenjNsqheP3JkcENprVMO8QqWYha_XjVZpCUiVjP9HBLhSpqQCED60xvAXAoYrP3B9-0_-6c_kxehifKbPTic_P5KXcSs7ZtEckO3VzdofAhdaVZ-ird8BV58CKA
openUrl ctx_ver=Z39.88-2004&ctx_enc=info%3Aofi%2Fenc%3AUTF-8&rfr_id=info%3Asid%2Fsummon.serialssolutions.com&rft_val_fmt=info%3Aofi%2Ffmt%3Akev%3Amtx%3Ajournal&rft.genre=article&rft.atitle=Minicells%3A+Versatile+vectors+for+targeted+drug+or+si%2FshRNA+cancer+therapy&rft.jtitle=Current+opinion+in+biotechnology&rft.au=MacDiarmid%2C+Jennifer+A&rft.au=Brahmbhatt%2C+Himanshu&rft.date=2011-12-01&rft.issn=0958-1669&rft.volume=22&rft.issue=6&rft.spage=909&rft.epage=916&rft_id=info:doi/10.1016%2Fj.copbio.2011.04.008&rft.externalDBID=ECK1-s2.0-S0958166911000711&rft.externalDocID=1_s2_0_S0958166911000711
thumbnail_m http://utb.summon.serialssolutions.com/2.0.0/image/custom?url=https%3A%2F%2Fcdn.clinicalkey.com%2Fck-thumbnails%2F09581669%2FS0958166911X00083%2Fcov150h.gif