Minicells: Versatile vectors for targeted drug or si/shRNA cancer therapy
Highlights ► Targeted drug or siRNA delivery in cancer remains a serious hurdle. ► Minicells provide a versatile solution for targeted drug or siRNA delivery. ► Minicell-based delivery packages nanoscale levels of drugs or siRNAs. ► In vivo xenografts in mice show dramatic enhancement of therapeutic...
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Published in | Current opinion in biotechnology Vol. 22; no. 6; pp. 909 - 916 |
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Main Authors | , |
Format | Journal Article |
Language | English |
Published |
England
Elsevier Ltd
01.12.2011
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Subjects | |
Online Access | Get full text |
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Summary: | Highlights ► Targeted drug or siRNA delivery in cancer remains a serious hurdle. ► Minicells provide a versatile solution for targeted drug or siRNA delivery. ► Minicell-based delivery packages nanoscale levels of drugs or siRNAs. ► In vivo xenografts in mice show dramatic enhancement of therapeutic index. ► Monkey toxicology trials show repeat dosing without toxicity or immunogenicity. |
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Bibliography: | http://dx.doi.org/10.1016/j.copbio.2011.04.008 ObjectType-Article-2 SourceType-Scholarly Journals-1 ObjectType-Feature-3 content type line 23 ObjectType-Review-1 ObjectType-Article-1 ObjectType-Feature-2 |
ISSN: | 0958-1669 1879-0429 |
DOI: | 10.1016/j.copbio.2011.04.008 |