Induction of pancreatic neoplasia in the KRAS / TP53 Oncopig

• Published in: Disease models & mechanisms Vol. 16; no. 1
• Main Authors: Mondal, Pinaki, Patel, Neesha S., Bailey, Katie, Aravind, Shruthishree, Cartwright, Sara B., Hollingsworth, Michael A., Lazenby, Audrey J., Carlson, Mark A.
• Format: Journal Article
• Language: English
• Published: England The Company of Biologists Ltd 01.01.2023; The Company of Biologists
• Subjects: Adenoviruses; Animal models; Animals; Animals, Genetically Modified; Cancer therapies; Carcinoma, Pancreatic Ductal - pathology; Catheters; Cellulitis; Cre recombinase; Drug dosages; FDA approval; Gene Expression Profiling; Hogs; Humans; K-Ras protein; Mice; Mortality; Necropsy; oncopig; Pancreas; Pancreatic cancer; Pancreatic Neoplasms; Pancreatic Neoplasms - pathology; porcine pancreatic cancer; Preprints; Proto-Oncogene Proteins p21(ras) - genetics; Proto-Oncogene Proteins p21(ras) - metabolism; R&D; Research & development; Small intestine; Swine; Therapeutic applications; Transcriptomes; Tumor Suppressor Protein p53; Tumors; Veins & arteries; United States > US; Oncopig; Pancreas; Porcine pancreatic cancer; Pancreatic cancer

The 5-year survival of pancreatic cancer (PC) remains low. Murine models may not adequately mimic human PC and can be too small for medical device development. A large-animal PC model could address these issues. We induced and characterized pancreatic tumors in Oncopigs (transgenic swine containing...