Biomarkers of Microbial Translocation and Macrophage Activation: Association With Progression of Subclinical Atherosclerosis in HIV-1 Infection

• Published in: The Journal of infectious diseases Vol. 206; no. 10; pp. 1558 - 1567
• Main Authors: Kelesidis, Theodoros, Kendall, Michelle A., Yang, Otto O., Hodis, Howard N., Currier, Judith S.
• Format: Journal Article
• Language: English
• Published: Oxford Oxford University Press 15.11.2012
• Subjects: Adult; AIDS; Anti-HIV Agents - therapeutic use; Atherosclerosis; Atherosclerosis - complications; Bacterial Translocation; Biological and medical sciences; Biomarkers - blood; Biomarkers - metabolism; Body mass index; Cholesterols; Cohort Studies; Female; Fundamental and applied biological sciences. Psychology; HDL lipoproteins; HIV; HIV infections; HIV Infections - blood; HIV Infections - complications; HIV Infections - drug therapy; HIV-1; HIV/AIDS; Human immunodeficiency virus; Human immunodeficiency virus 1; Human viral diseases; Humans; Infectious diseases; Lipopolysaccharide Receptors - blood; Lipopolysaccharide Receptors - metabolism; Lipopolysaccharides - blood; Lipopolysaccharides - metabolism; Macrophage Activation - physiology; Major and Brief Reports; Male; Medical sciences; Memory interference; Microbiology; Middle Aged; Miscellaneous; Modeling; Protease Inhibitors - therapeutic use; Rates of change; Retrospective Studies; Viral diseases; Viral diseases of the lymphoid tissue and the blood. Aids; Virology; Immunopathology; HIV-1 virus; Retroviridae; Biological marker; Cardiovascular disease; AIDS; Immune deficiency; Lentivirus; Vascular disease; Virus; Infection; Viral disease; Atherosclerosis; Human immunodeficiency virus; Macrophage

Background. The relationships between soluble CD 14 (sCD14), endotoxin (lipopolysaccharide [LPS]), and progression of atherosclerosis have not been defined in human immunodeficiency virus (HIV) infection. Methods. We retrospectively assessed serum sCD14 and LPS levels of 91 subjects in a prospective...