AOP report: Development of an adverse outcome pathway for oxidative DNA damage leading to mutations and chromosomal aberrations

• Published in: Environmental and molecular mutagenesis Vol. 63; no. 3; pp. 118 - 134
• Main Authors: Cho, Eunnara, Allemang, Ashley, Audebert, Marc, Chauhan, Vinita, Dertinger, Stephen, Hendriks, Giel, Luijten, Mirjam, Marchetti, Francesco, Minocherhomji, Sheroy, Pfuhler, Stefan, Roberts, Daniel J., Trenz, Kristina, Yauk, Carole L.
• Format: Journal Article
• Language: English
• Published: Hoboken, USA John Wiley & Sons, Inc 01.03.2022; Wiley Subscription Services, Inc; Wiley-Blackwell
• Subjects: Antioxidants; Aop Report; Chromosome aberrations; Damage; Deoxyribonucleic acid; DNA; DNA damage; DNA repair; Environmental science; Free radicals; Genotoxicity; Intermediates; Life Sciences; Mutation; Reactive oxygen species; Repair; Toxicology

The Genetic Toxicology Technical Committee (GTTC) of the Health and Environmental Sciences Institute (HESI) is developing adverse outcome pathways (AOPs) that describe modes of action leading to potentially heritable genomic damage. The goal was to enhance the use of mechanistic information in genot...