Bioequivalence and Food Effect Assessment of Two Fixed‐Dose Combination Formulations of Telmisartan‐Hydrochlorothiazide Tablets in Chinese Healthy Subjects - Hu, Minwan; Yang, Man; Zhang, Shuyu; Li, Jiangfan; Pang, Hongxian; Pei, Yingzi; Guo, Chao; Wang, Xuhong (Clinical and translational science, 2025)
Keywords: Administration, Oral; Adult; Antihypertensives; Area Under Curve; Asian People; Benzimidazoles - administration & dosage; Benzimidazoles - adverse effects; Benzimidazoles - pharmacokinetics; Benzoates - administration & dosage; Benzoates - pharmacokinetics; Bioequivalence; Blood pressure; China; Clinical trials; Cross-Over Studies; Disease; Drug Combinations; Drug dosages; East Asian People; Enzymes; Fasting; FDA approval; Female; fixed‐dose combination (FDC); Food-Drug Interactions; Generic drugs; Healthy Volunteers; Hepatitis; Humans; Hydrochlorothiazide; Hydrochlorothiazide - administration & dosage; Hydrochlorothiazide - adverse effects; Hydrochlorothiazide - pharmacokinetics; Hypertension; Integrity Check; Male; Metabolism; Middle Aged; Patients; Pharmaceuticals; Pharmacokinetics; Plasma; Regulatory approval; Tablets; Tandem Mass Spectrometry; telmisartan; Telmisartan - administration & dosage; Telmisartan - adverse effects; Telmisartan - pharmacokinetics; Therapeutic Equivalency; Young Adult; China; Beijing China; pharmacokinetics; fixed‐dose combination (FDC); telmisartan; bioequivalence; hydrochlorothiazide