Age‐related intrinsic changes in human bone‐marrow‐derived mesenchymal stem cells and their differentiation to osteoblasts

• Published in: Aging cell Vol. 7; no. 3; pp. 335 - 343
• Main Authors: Zhou, Shuanhu, Greenberger, Joel S., Epperly, Michael W., Goff, Julie P., Adler, Carolyn, LeBoff, Meryl S., Glowacki, Julie
• Format: Journal Article
• Language: English
• Published: Oxford, UK Blackwell Publishing Ltd 01.06.2008
• Subjects: Adolescent; Adult; Aged; Aged, 80 and over; aging; apoptosis; Apoptosis - physiology; Bone Marrow Cells - cytology; Bone Marrow Cells - physiology; Cell Differentiation - physiology; Cell Proliferation; Cellular Senescence - physiology; Female; Humans; Male; marrow stromal cells; mesenchymal stem cells; Mesenchymal Stem Cells - cytology; Mesenchymal Stem Cells - physiology; Middle Aged; osteoblast differentiation; Osteoblasts - cytology; Osteoblasts - metabolism; Osteoblasts - physiology; p53; proliferation; Tumor Suppressor Protein p53 - metabolism; Up-Regulation

Summary In vivo and in vitro studies indicate that a subpopulation of human marrow‐derived stromal cells (MSCs, also known as mesenchymal stem cells) has potential to differentiate into multiple cell types, including osteoblasts. In this study, we tested the hypothesis that there are intrinsic effec...