Identification and Biological Evaluation of Secondary Metabolites from the Endolichenic Fungus Aspergillus versicolor

• Published in: Chemistry & biodiversity Vol. 12; no. 4; pp. 575 - 592
• Main Authors: Li, Xiao-Bin, Zhou, Yan-Hui, Zhu, Rong-Xiu, Chang, Wen-Qiang, Yuan, Hui-Qing, Gao, Wei, Zhang, Lu-Lu, Zhao, Zun-Tian, Lou, Hong-Xiang
• Format: Journal Article
• Language: English
• Published: Zürich WILEY-VCH Verlag 01.04.2015; WILEY‐VCH Verlag; Wiley Subscription Services, Inc
• Subjects: Acids; Antifungal activity; Antifungal Agents - chemistry; Antifungal Agents - isolation & purification; Antifungal Agents - pharmacology; Antineoplastic Agents, Phytogenic - chemistry; Antineoplastic Agents, Phytogenic - pharmacology; Aspergillus - chemistry; Aspergillus - metabolism; Aspergillus versicolor; Bioassays; Bisabolane sesquiterpenoid; Candida albicans; Candida albicans - drug effects; Cell Line, Tumor - drug effects; Circular Dichroism; Cytotoxic activity; Dichroism; Drug Evaluation, Preclinical - methods; Endolichenic fungus; Ethers; Fungi; Humans; Lichens - microbiology; Lobaria quercizans; Magnetic Resonance Spectroscopy; Metabolites; Molecular Structure; Phenyl Ethers - chemistry; Phenyl Ethers - pharmacology; Pyrogallol; Secondary Metabolism; Secondary metabolites; Sesquiterpenes - chemistry; Sesquiterpenes - isolation & purification; Sesquiterpenoids; Structure-Activity Relationship; Tumor cell lines; Endolichenic fungus; Fungi; Antifungal activity; Aspergillus versicolor; Sesquiterpenoids; Bisabolane sesquiterpenoid; Cytotoxic activity

A chemical investigation of the endolichenic fungus Aspergillus versicolor (125a), which was found in the lichen Lobaria quercizans, resulted in the isolation of four novel diphenyl ethers, named diorcinols F–H (1–3, resp.) and 3‐methoxyviolaceol‐II (4), eight new bisabolane sesquiterpenoids, named...