DISC1 in adult ADHD patients: An association study in two European samples
The DISC1 gene was named after its discovery in a Scottish pedigree with schizophrenia (SCZ) patients. However, subsequent studies have shown association of DISC1 variants with a range of different neurocognitive phenotypes and psychiatric disorders, including bipolar disorder (BPD), and major depre...
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Published in | American journal of medical genetics. Part B, Neuropsychiatric genetics Vol. 162B; no. 3; pp. 227 - 234 |
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Main Authors | , , , , , , |
Format | Journal Article |
Language | English |
Published |
Hoboken
Wiley Subscription Services, Inc., A Wiley Company
01.04.2013
Wiley Subscription Services, Inc |
Subjects | |
Online Access | Get full text |
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Summary: | The DISC1 gene was named after its discovery in a Scottish pedigree with schizophrenia (SCZ) patients. However, subsequent studies have shown association of DISC1 variants with a range of different neurocognitive phenotypes and psychiatric disorders, including bipolar disorder (BPD), and major depression. Attention‐deficit/hyperactivity disorder (ADHD) shares some symptoms with BPD and ADHD patients often suffer from comorbid affective disorders. We wanted to examine the role of DISC1 in ADHD, and with comorbid symptoms of mood disorders. Eleven single nucleotide polymorphisms (SNPs) previously implicated in SCZ and BPD, and a DISC1 duplication involving exon 1, were genotyped in 561 adult ADHD cases and 713 controls of Norwegian ancestry. The intronic SNP rs1538979 was associated with ADHD in the Norwegian sample [odds ratio (OR): 1.33, 95% confidence interval (CI) 1.03–1.73, P = 0.03] and replicated in a Spanish adult ADHD sample of 694 cases and 735 controls, using the tagging SNP rs11122330 (meta‐analysis: P = 0.008, OR 1.25, 95% CI 1.06–1.47). In the Norwegian ADHD sample we also observed an association between the Phe607‐variant of rs6675281 and a positive score on the Mood Disorder Questionnaire (MDQ; OR = 1.44, 95% CI 1.08–1.93, P = 0.01). To our knowledge, this is the first study to show an association between DISC1 variants and ADHD. Our study suggests that further studies are warranted to resolve if DISC1 variation is involved in several common neurodevelopmental disorders including ADHD. © 2013 Wiley Periodicals, Inc. |
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Bibliography: | istex:0DDB85163D2F3EB0B3E7443A3FB9D5E39E1C503A ark:/67375/WNG-06XQL71R-F Instituto de Salud Carlos III - No. PI11/00571; No. PI11/01629 Plan Nacional sobre Drogas - No. 2011/0080 Agència de Gestió d'Ajuts Universitaris i de Recerca- - No. AGAUR 2009SGR0971 Fundació La Marató de TV3 - No. 092330/31 How to Cite this Article: Jacobsen KK, Halmøy A, Sánchez-Mora C, Ramos-Quiroga JA, Cormand B, Haavik J, Johansson S. 2013. DISC1 in Adult ADHD Patients: An Association Study in Two European Samples. Am J Med Genet Part B 162B:227-234. Research Council of Norway None of the authors report any conflict of interest. ArticleID:AJMG32136 K.G. Jebsen Foundation Ministerio de Economía y Competitividad, Spain - No. SAF2012-33484 Regional Health Authority of Western Norway in Adult ADHD Patients: An Association Study in Two European Samples. Am J Med Genet Part B 162B:227–234. DISC1 How to Cite this Article: Jacobsen KK, Halmøy A, Sánchez‐Mora C, Ramos‐Quiroga JA, Cormand B, Haavik J, Johansson S. 2013. ObjectType-Article-1 SourceType-Scholarly Journals-1 ObjectType-Feature-2 content type line 23 ObjectType-Article-2 ObjectType-Feature-1 |
ISSN: | 1552-4841 1552-485X |
DOI: | 10.1002/ajmg.b.32136 |