Exercise Induces Different Molecular Responses in Trained and Untrained Human Muscle

• Published in: Medicine and science in sports and exercise Vol. 52; no. 8; p. 1679
• Main Authors: Moberg, Marcus, Lindholm, Malene E, Reitzner, Stefan M, Ekblom, BjÖrn, Sundberg, Carl-Johan, Psilander, Niklas
• Format: Journal Article
• Language: English
• Published: United States 01.08.2020
• Subjects: Adaptation, Physiological - genetics; Adult; AMP-Activated Protein Kinases - metabolism; Elongation Factor 2 Kinase - metabolism; Female; Gene Expression; Histone Methyltransferases - metabolism; Humans; Male; Methylation; Muscle Proteins - metabolism; Muscle, Skeletal - metabolism; MyoD Protein - metabolism; Myogenin - metabolism; Peroxisome Proliferator-Activated Receptor Gamma Coactivator 1-alpha - metabolism; Phosphorylation; Promoter Regions, Genetic; Resistance Training; RNA, Messenger - metabolism; Signal Transduction; SKP Cullin F-Box Protein Ligases - metabolism; Young Adult

Human skeletal muscle is thought to have heightened sensitivity to exercise stimulus when it has been previously trained (i.e., it possesses "muscle memory"). We investigated whether basal and acute resistance exercise-induced gene expression and cell signaling events are influenced by pre...