Prostaglandin E2 enhances hematopoietic stem cell homing, survival, and proliferation

• Published in: Blood Vol. 113; no. 22; pp. 5444 - 5455
• Main Authors: Hoggatt, Jonathan, Singh, Pratibha, Sampath, Janardhan, Pelus, Louis M.
• Format: Journal Article
• Language: English
• Published: Washington, DC Elsevier Inc 28.05.2009; Americain Society of Hematology; American Society of Hematology
• Series: Hematopoiesis and Stem Cells
• Subjects: Animals; Apoptosis - drug effects; Biological and medical sciences; Cell Movement - drug effects; Cell Proliferation - drug effects; Cell Survival - drug effects; Cells, Cultured; Dinoprostone - pharmacology; Graft Survival - drug effects; Hematologic and hematopoietic diseases; Hematopoiesis and Stem Cells; Hematopoietic Stem Cell Mobilization - methods; Hematopoietic Stem Cells - drug effects; Hematopoietic Stem Cells - metabolism; Hematopoietic Stem Cells - physiology; Humans; Medical sciences; Mice; Mice, Inbred C57BL; Mice, Transgenic; Models, Biological; Receptors, CXCR4 - metabolism; Receptors, Prostaglandin E - metabolism; Transplantation Conditioning - methods; Cell proliferation; Cell survival; Hematology; Eicosanoid; Stem cell; Arachidonic acid derivatives; Hematopoietic cell; Prostaglandin E2; Homing phenomenon

Adult hematopoietic stem cells (HSCs) are routinely used to reconstitute hematopoiesis after myeloablation; however, transplantation efficacy and multilineage reconstitution can be limited by inadequate HSC number, or poor homing, engraftment, or self-renewal. Here we report that mouse and human HSC...