Prostate cancer stem‐like cells/cancer‐initiating cells have an autocrine system of hepatocyte growth factor

• Published in: Cancer science Vol. 104; no. 4; pp. 431 - 436
• Main Authors: Nishida, Sachiyo, Hirohashi, Yoshihiko, Torigoe, Toshihiko, Inoue, Ryuta, Kitamura, Hiroshi, Tanaka, Toshiaki, Takahashi, Akari, Asanuma, Hiroko, Masumori, Naoya, Tsukamoto, Taiji, Sato, Noriyuki
• Format: Journal Article
• Language: English
• Published: England John Wiley and Sons Inc 01.04.2013
• Subjects: Animals; Cell Line, Tumor; Gene Knockout Techniques; Hepatocyte Growth Factor - metabolism; Humans; Male; Mice; Mice, Inbred NOD; Mice, SCID; Neoplastic Stem Cells - metabolism; Original; Prostatic Neoplasms - metabolism; Prostatic Neoplasms - pathology; Proto-Oncogene Proteins c-met - genetics; Proto-Oncogene Proteins c-met - metabolism; Transplantation, Heterologous

Prostate cancer cells include a small population of cancer stem‐like cells (CSCs)/cancer‐initiating cells (CICs) that have roles in initiation and progression of the cancer. Recently, we isolated prostate CSCs/CICs as aldehyde dehydrogenase 1‐highh (ALDH1high) cells using the ALDEFLUOR assay; howeve...