Association of the IL‐6R rs2228145 polymorphism with diabetic nephropathy: A case‐control study

• Published in: Journal of diabetes investigation Vol. 16; no. 8; pp. 1463 - 1472
• Main Authors: Izakovicova, Pavla, Slezakova, Simona, Deissova, Tereza, Poskerova, Hana, Borilova Linhartova, Petra, Dusek, Ladislav, Kankova, Katerina, Izakovicova Holla, Lydie
• Format: Journal Article
• Language: English
• Published: Japan John Wiley & Sons, Inc 01.08.2025; John Wiley and Sons Inc; Wiley
• Subjects: Adult; Aged; Birth control; Blood glucose; Breastfeeding & lactation; Case-Control Studies; Cholesterol; Czech Republic - epidemiology; Diabetes; Diabetes mellitus; Diabetes Mellitus, Type 1 - complications; Diabetes Mellitus, Type 1 - genetics; Diabetes Mellitus, Type 2 - complications; Diabetes Mellitus, Type 2 - genetics; Diabetic Nephropathies - epidemiology; Diabetic Nephropathies - genetics; Diabetic nephropathy; Diabetic neuropathy; Enrollments; Enzymes; Female; Gene polymorphism; Genetic Predisposition to Disease; Genotype; Genotype & phenotype; Glomerular filtration rate; Gum disease; Haplotypes; Hemoglobin; Homozygotes; Humans; IL‐6; Inflammation; Insulin resistance; Interleukin 6; Interleukin-6 - genetics; Kidney diseases; Male; Metabolism; Middle Aged; Nephropathy; Neuropathy; Original; Periodontitis; Polymorphism; Polymorphism, Single Nucleotide; Polymorphisms; Receptors, Interleukin-6 - genetics; Renal replacement therapy; Retinopathy; Single-nucleotide polymorphism; Czech Republic; England; United Kingdom > UK; United States > US; Polymorphisms; Diabetic nephropathy; IL‐6

ABSTRACT Introduction The pathogenesis of diabetes mellitus (DM) and its complications has been previously linked to elevated levels of interleukin‐6 (IL‐6); IL‐6 triggers intracellular pathways through interaction with the IL‐6 receptor (IL‐6R). This study aimed to determine the association of sing...